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1 | 34612556 | 10.1002/ejhf.2356 | COVID-19 vaccination in patients with heart failure: a position paper of the Heart Failure Association of the European Society of Cardiology. | 6 October 2021 00:00 | Journal Article | CY;KZ;DK;PL;EG;IT;ES;IE;GR;DE;SE;IL;PT;RO;RS;GB;RU;SI;BE;HR;FR | en | IRCCS San Raffaele Pisana, Rome, Italy.;Department of Heart Diseases, Wroclaw Medical University & Centre for Heart Diseases, University Hospital, Wroclaw, Poland.;Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St George's, University of London, St George's Hospital, London, UK.;Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.;Faculty of Medicine, Kasr Al Ainy, Department of Cardiology, Cairo University, Giza, Egypt.;Heart Failure - Transplant - Mechanical Circulatory Support Unit, Onassis Cardiac Surgery Center, Athens, Greece.;Department of Cardiology, and Berlin Institute of Health Center for Regenerative Therapies, German Centre for Cardiovascular Research partner site Berlin, Charité Universitätsmedizin, Berlin, Germany.;Heart Institute, Hospital Universitari Germans Trias i Pujol, Badalona & CIBERCV, I | Patients with heart failure (HF) who contract SARS-CoV-2 infection are at a higher risk of cardiovascular and non-cardiovascular morbidity and mortality. Regardless of therapeutic attempts in COVID-19, vaccination remains the most promising global approach at present for controlling this disease. There are several concerns and misconceptions regarding the clinical indications, optimal mode of delivery, safety and efficacy of COVID-19 vaccines for patients with HF. This document provides guidance to all healthcare professionals regarding the implementation of a COVID-19 vaccination scheme in patients with HF. COVID-19 vaccination is indicated in all patients with HF, including those who are immunocompromised (e.g. after heart transplantation receiving immunosuppressive therapy) and with frailty syndrome. It is preferable to vaccinate against COVID-19 patients with HF in an optimal clinical state, which would include clinical stability, adequate hydration and nutrition, optimized treatme | Giuseppe Rosano;Ewa A Jankowska;Robin Ray;Marco Metra;Magdy Abdelhamid;Stamatis Adamopoulos;Stefan D Anker;Antoni Bayes-Genis;Yuri Belenkov;Tuvia B Gal;Michael Böhm;Ovidiu Chioncel;Alain Cohen-Solal;Dimitrios Farmakis;Gerasimos Filippatos;Arantxa González;Finn Gustafsson;Loreena Hill;Tiny Jaarsma;Fadi Jouhra;Mitja Lainscak;Ekaterini Lambrinou;Yury Lopatin;Lars H Lund;Davor Milicic;Brenda Moura;Wilfried Mullens;Massimo F Piepoli;Piotr Ponikowski;Amina Rakisheva;Arsen Ristic;Gianluigi Savarese;Petar Seferovic;Michele Senni;Thomas Thum;Carlo G Tocchetti;Sophie Van Linthout;Maurizio Volterrani;Andrew J S Coats | COVID-19;Heart failure;SARS-CoV-2;Vaccination | pubmed | ||||||
2 | 34449403 | 10.2196/30444 | Detection of Spatiotemporal Clusters of COVID-19-Associated Symptoms and Prevention Using a Participatory Surveillance App: Protocol for the @choum Study. | 6 October 2021 00:00 | Journal Article | CH;FR | en | 1929-0748 | Division of Primary Care, Geneva University Hospitals, Geneva, Switzerland.;Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.;Group of Geographic Information Research and Analysis in Population Health, Geneva University Hospitals, Geneva, Switzerland.;Laboratory of Geographic Information Systems, School of Architecture, Civil and Environmental Engineering, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland.;Department of Oncology, Geneva University Hospitals, Geneva, Switzerland.;Direction of Information Systems, Geneva University Hospitals, Geneva, Switzerland.;Communication Directorate, Geneva University Hospitals, Geneva, Switzerland.;Center for Research and Interdisciplinarity, INSERM U1284, University of Paris, Paris, France.;Division of Infectious Disease and Laboratory of Virology, Geneva University Hospitals, Geneva, Switzerland.;Center for Emerging Viral Diseases, Geneva University Hospitals, Geneva, | JMIR Research Protocols | The early detection of clusters of infectious diseases such as the SARS-CoV-2-related COVID-19 disease can promote timely testing recommendation compliance and help to prevent disease outbreaks. Prior research revealed the potential of COVID-19 participatory syndromic surveillance systems to complement traditional surveillance systems. However, most existing systems did not integrate geographic information at a local scale, which could improve the management of the SARS-CoV-2 pandemic. | David De Ridder;Andrea Jutta Loizeau;José Luis Sandoval;Frédéric Ehrler;Myriam Perrier;Albert Ritch;Guillemette Violot;Marc Santolini;Bastian Greshake Tzovaras;Silvia Stringhini;Laurent Kaiser;Jean-François Pradeau;Stéphane Joost;Idris Guessous | COVID-19;SARS-CoV-2;digital health;digital surveillance;epidemiology;infectious disease;mHealth;mobile app;participatory surveillance;public health;space-time clustering;surveillance | pubmed | ||||
3 | 34614016 | 10.1371/journal.pone.0257840 | The major worldwide stress of healthcare professionals during the first wave of the COVID-19 pandemic - the international COVISTRESS survey. | 6 October 2021 00:00 | Journal Article | GB;CL;TW;CH;FR;HK;SA;PT | en | Department of Anesthesiology and Critical Care, University Hospital of Toulouse, University Toulouse 3-Paul Sabatier, Toulouse, France.;UMR EFTS, Université Toulouse 2 -Jean Jaurès, Toulouse, France.;Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, University Hospital of Toulouse, CHU Toulouse, France.;Hong Kong Baptist University, Physical Education and Health, Centre for Health and Exercise Science Research, Kowloon Tong, Hong Kong.;Universidad Finis-Terrae, Hospital Dr. Luis-Valentìn-Ferrada, El-Carmen, Maipù, Chile.;King Abdulaziz University, Saudi Arabia, College of Sciences and Theoretical Studies, Riyadh, Saudi Arabia.;University of Taipei, Exercise and Health Science, Taipei, Taiwan.;Université de Genève, UNIGE, Fondation INARTIS, Genève, Switzerland.;ISPA-Instituto Universitário, Ordem dos Psicólogos Portugueses, APPsyCI-Applied Psychology Research Center Capabilities & Inclusion, Lisboa, Portugal.;University Hospital of Clermont Ferrand, CHU | The COVID-19 pandemic has initiated an upheaval in society and has been the cause of considerable stress during this period. Healthcare professionals have been on the front line during this health crisis, particularly paramedical staff. The aim of this study was to assess the high level of stress of healthcare workers during the first wave of the pandemic. | Sébastien Couarraze;Louis Delamarre;Fouad Marhar;Binh Quach;Jiao Jiao;Raimundo Avilés Dorlhiac;Foued Saadaoui;Andy Su-I Liu;Benoït Dubuis;Samuel Antunes;Nicolas Andant;Bruno Pereira;Ukadike C Ugbolue;Julien S Baker;Maëlys Clinchamps;Frédéric Dutheil | pubmed | |||||||
4 | 34612616 | 10.23736/s0375-9393.21.16003-1 | Risk-stratifying COVID-19 patients using lung ultrasonography: an underutilized tool with growing evidence. | 6 October 2021 00:00 | Journal Article | AE;FR;US | en | 0375-9393,1827-1596 | Division of Pulmonary and Critical Care, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.;Department of Critical Care Medicine, Critical Care Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates - mallatjihad@gmail.com.;Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.;Normandy University, UNICAEN, ED 497, Caen, France. | Minerva Anestesiologica | Boulos Nassar;Jihad Mallat | pubmed | ||||||
5 | 34610987 | 10.1212/wnl.0000000000012753 | Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis. | 5 October 2021 00:00 | Journal Article | ES;IT;US;BE;DE;FR;TR;SE;AU;BR;PS;KW;AR;DK;GB;BG | en | CORe, Department of Medicine, The University of Melbourne, Australia steve.simpsonyap@unimelb.edu.au.;Neuroepidemiology Unit, Melbourne School of Population & Global Health, The University of Melbourne, Australia.;Menzies Institute for Medical Research, University of Tasmania, Australia.;ESAT-STADIUS, KU Leuven, Belgium.;CORe, Department of Medicine, The University of Melbourne, Australia.;Melbourne MS Centre, Department of Neurology, Royal Melbourne Hospital, Australia.;MS International Federation, United Kingdom.;Department of Clinical Neuroscience, Swedish MS Registry, Sweden.;Department of Neurology, CHU Pontchaillou, France.;Karolinska Institutet, Sweden.;Biomedical Research Institute - Data Science Institute, Hasselt University, Belgium.;Department of Medical Informatics, University Medical Center Göttingen, Germany.;Department of Computer Science and AI, KU Leuven, Belgium.;QMENTA, Spain.;Medpace Reference Laboratories, Molecular Unit, Leuven, Belgium.;iConquerMS People-Powered | People with multiple sclerosis (MS) are a vulnerable group for severe COVID- 19, particularly those taking immunosuppressive disease-modifying therapies (DMTs). We examined the characteristics of COVID-19 severity in an international sample of people with MS. | Steve Simpson-Yap;Edward De Brouwer;Tomas Kalincik;Nick Rijke;Jan A Hillert;Clare Walton;Gilles Edan;Yves Moreau;Tim Spelman;Lotte Geys;Tina Parciak;Clement Gautrais;Nikola Lazovski;Ashkan Pirmani;Amin Ardeshirdavanai;Lars Forsberg;Anna Glaser;Robert McBurney;Hollie Schmidt;Arnfin B Bergmann;Stefan Braune;Alexander Stahmann;Rodden Middleton;Amber Salter;Robert J Fox;Anneke van der Walt;Helmut Butzkueven;Raed Alroughani;Serkan Ozakbas;Juan I Rojas;Ingrid van der Mei;Nupur Nag;Rumen Ivanov;Guilherme Sciascia do Olival;Alice Estavo Dias;Melinda Magyari;Doralina Brum;Maria Fernanda Mendes;Ricardo N Alonso;Richard S Nicholas;Johana Bauer;Aníbal Sebastián Chertcoff;Anna Zabalza;Georgina Arrambide;Alex Fidao;Giancarlo Comi;Liesbet Peeters | pubmed | |||||||
6 | 34609341 | 10.1097/ncm.0000000000000530 | Predictors for Telephone Outreach Post-hospital Discharge. | 5 October 2021 00:00 | Journal Article | FR;US | en | 1932-8087 | Franz H. Vergara, DNP/PhD, RN, ONC, CCM, was a Patient Access Line (PAL) case manager who conducted the inaugural nurse-led telephone follow-up call at The Johns Hopkins Hospital, Baltimore, Maryland. The PAL department was a successful program, preventing readmissions of 777 patients and reducing $11.8 million within 40 months. Currently, Dr. Vergara is a director at Inova Mount Vernon Hospital, Alexandria, Virginia.;Chakra Budhathoki, PhD, is a associate professor and biostatistician, The Johns Hopkins University School of Nursing, Baltimore, Maryland.;Daniel J. Sheridan, PhD, RN, FAAN, is a faculty member, The Johns Hopkins University School of Nursing, Baltimore, Maryland. Dr. Sheridan served as Dr. Vergara's dissertation cochairman at the Goldfarb School of Nursing, Barnes-Jewish College, St. Louis, Missouri.;Jean E. Davis, PhD, RN, FAAN, is a PhD program director and professor, University of South Carolina, College of Nursing. Dr. Davis served as Dr. Vergara's dissertation cochai | Professional Case Management | The specific aims of this study were to examine whether sociodemographic variables and medical-surgical diagnoses were associated with telephone follow-up (TFU) reach rates, emergency department visits, and hospital readmissions. | Franz H Vergara;Chakra Budhathoki;Daniel J Sheridan;Jean E Davis;Nancy J Sullivan | pubmed | |||||
7 | 34611893 | 10.1111/bjd.20707 | Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreak. | 5 October 2021 00:00 | Journal Article | FR | en | Dermatology Department, AP-HP, Hôpital Saint-Louis, F-75010, Paris, France.;Université de Paris, Human Immunology Pathophysiology Immunotherapy, INSERM U976, Institut de Recherche Saint-Louis, F-75010, Paris, France.;Pathology Department, AP-HP, Hôpital Saint-Louis, F-75010, Paris, France.;Université de Paris, Imagine Institute, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM U1163, F-75015, Paris, France.;Department of Internal Medicine, National Reference Centre for Rare Systemic Autoimmune Diseases, AP-HP, Hôpital Cochin, F-75014, Paris, France.;Université de Paris, PARCC, INSERM, F-75006, Paris, France.;Emergency Department, AP-HP, Georges Pompidou European Hospital, F-75015, Paris, France.;Immunobiology Department, AP-HP, Hôpital Saint-Louis, F-75010, Paris, France.;Institut Pasteur, Virus and Immunity Unit, F-75015, Paris, France.;Institut Pasteur, Translational Immunology Lab, F-75015, Paris, France.;Institut Pasteur, Cytometry and Biomarkers UTechS, CRT, F | The outbreak of chilblain-like lesions (CLL) during the COVID-19 pandemic has been reported extensively, potentially related to SARS-CoV-2 infection, yet its underlying pathophysiology is unclear. | L Frumholtz;J-D Bouaziz;M Battistella;J Hadjadj;R Chocron;D Bengoufa;H Le Buanec;L Barnabei;S Meynier;O Schwartz;L Grzelak;N Smith;B Charbit;D Duffy;N Yatim;A Calugareanu;A Philippe;C L Guerin;B Joly;V Siguret;L Jaume;H Bachelez;M Bagot;F Rieux-Laucat;S Maylin;J Legoff;C Delaugerre;N Gendron;D M Smadja;C Cassius | [{"grantid": "AIROCovid", "agency": "Agence Nationale de la Recherche", "country": ""}, {"grantid": "Investment for the Future", "agency": "Agence Nationale de la Recherche", "country": ""}, {"agency": "French Friends of Sheba Tel Hashomer Hospital", "country": ""}, {"agency": "Institut National de la Santé et de la Recherche Médicale", "country": ""}, {"agency": "Fondation Bettencourt Schueller", "country": ""}, {"agency": "Fondation pour la Recherche Médicale", "country": ""}] | Agence Nationale de la Recherche;Agence Nationale de la Recherche;French Friends of Sheba Tel Hashomer Hospital;Institut National de la Santé et de la Recherche Médicale;Fondation Bettencourt Schueller;Fondation pour la Recherche Médicale | pubmed | |||||
8 | 34610031 | 10.1371/journal.pone.0257646 | Humoral response after SARS-CoV-2 mRNA vaccines in dialysis patients: Integrating anti-SARS-CoV-2 Spike-Protein-RBD antibody monitoring to manage dialysis centers in pandemic times. | 5 October 2021 00:00 | Journal Article | FR | en | 1932-6203 | Clinique Saint-Augustin-CTMR, ELSAN, Bordeaux, France. | PLOS ONE | Dialysis patients are both the most likely to benefit from vaccine protection against SARS-CoV-2 and at the highest risk of not developing an immune response. Data from the medical field are thus mandatory. We report our experience with a BNT162b2-mRNA vaccine in a retrospective analysis of 241 dialysis patients including 193 who underwent anti-Spike-Protein-Receptor-Binding-Domain (RBD) IgG analysis. We show that a pro-active vaccine campaign is effective in convincing most patients to be vaccinated (95%) and frequently elicits a specific antibody response (94.3% after two doses and 98.4% after three doses). Only immunocompromised Status is associated with lack of seroconversion (OR 7.6 [1.5-38.2], p = 0.02). We also identify factors associated with low response (last quartile; IgG<500AU/mL): immunocompromised status, age, absence of RAAS inhibitors, low lymphocytes count, high C Reactive Protein; and with high response (high quartile; IgG>7000AU/mL): age; previous SARS-CoV-2 infectio | Thomas Bachelet;Jean-Philippe Bourdenx;Charlie Martinez;Simon Mucha;Philippe Martin-Dupont;Valerie Perier;Antoine Pommereau | pubmed | |||||
9 | 34610808 | 10.1186/s12889-021-11822-5 | The trajectory of COVID-19 pandemic and handwashing adherence: findings from 14 countries. | 5 October 2021 00:00 | Journal Article | PL;CA;IT;IE;MY;GM;CN;CH;DE;RO;FR;AU;IL;SG;GB;PT | en | 1471-2458 | Wroclaw Faculty of Psychology, SWPS University of Social Sciences and Humanities, 30b Ostrowskiego Street, PL-53-238, Wroclaw, Poland.;School of Psychology, Deakin University, Melbourne, Australia.;Department of Psychology, Babes-Bolyai University, Cluj-Napoca, Romania.;Faculty of Kinesiology, University of New Brunswick, Fredericton, Canada.;Department of General Psychology, University of Padova, Padova, Italy.;Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Serrekunda, Gambia.;School of Psychological and Cognitive Sciences, Peking University, Beijing, China.;Institute of Environmental Health, Medical School, University of Lisbon, Lisbon, Portugal.;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.;Melbourne Centre for Behaviour Change, Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia.;Department of Education and Psychology, Freie Universität Berlin, Berlin, | BMC Public Health | The COVID-19 pandemic has affected people's engagement in health behaviors, especially those that protect individuals from SARS-CoV-2 transmission, such as handwashing/sanitizing. This study investigated whether adherence to the World Health Organization's (WHO) handwashing guidelines (the outcome variable) was associated with the trajectory of the COVID-19 pandemic, as measured by the following 6 indicators: (i) the number of new cases of COVID-19 morbidity/mortality (a country-level mean calculated for the 14 days prior to data collection), (ii) total cases of COVID-19 morbidity/mortality accumulated since the onset of the pandemic, and (iii) changes in recent cases of COVID-19 morbidity/mortality (a difference between country-level COVID-19 morbidity/mortality in the previous 14 days compared to cases recorded 14-28 days earlier). | Zofia Szczuka;Charles Abraham;Adriana Baban;Sydney Brooks;Sabrina Cipolletta;Ebrima Danso;Stephan U Dombrowski;Yiqun Gan;Tania Gaspar;Margarida Gaspar de Matos;Konstadina Griva;Michelle Jongenelis;Jan Keller;Nina Knoll;Jinjin Ma;Mohammad Abdul Awal Miah;Karen Morgan;William Peraud;Bruno Quintard;Vishna Shah;Konstantin Schenkel;Urte Scholz;Ralf Schwarzer;Maria Siwa;Kamil Szymanski;Diana Taut;Silvia C M Tomaino;Noa Vilchinsky;Hodaya Wolf;Aleksandra Luszczynska | COVID-19;Cross-country;Hand hygiene;Morbidity;Mortality;Pandemic | pubmed | ||||
10 | 34612818 | 10.1684/pnv.2021.0955 | Vitamin D supplementation and COVID-19: expert consensus and guidelines. | 5 October 2021 00:00 | Journal Article | FR | en | Département de gériatrie et Centre mémoire ressources recherche, Centre de recherche sur l'autonomie et la longévité, Centre hospitalier universitaire, Angers, France, UPRES EA 4638, Université d'Angers, Angers, France, Gérontopôle Autonomie Longévité des Pays de la Loire, Nantes, France.;Service des explorations fonctionnelles, Hôpital Necker-Enfants malades, AP-HP Paris, France. | After 12 months of viral circulation, the SARS-CoV-2 has infected millions of people around the world, leaving hundreds of thousands dead. Given the lack of effective therapy and vaccination against COVID-19, focusing on the immediate repurposing of existing drugs gives some hope of curbing the pandemic. Vitamin D is a possible candidate drug which is discussed in a high number of publications. Randomised clinical trials have shown that vitamin D supplementation significantly reduces the risk of respiratory infections. There is also a great deal of evidence that hypovitaminosis D is an independent (and easily modifiable) risk factor for severe forms of COVID-19 and death. Vitamin D supplementation is a simple, safe and inexpensive measure, which is effective in correcting hypovitaminosis D, present in 40-50% of the French population and in more than 80% of adults with COVID-19. In this position paper, we propose simple regimens (adapted to the pharmaceutical forms currently available i | Cédric Annweiler;Jean-Claude Souberbielle | COVID-19;SARS-CoV-2;guidelines;supplementation;vitamin D | pubmed | ||||||
11 | 34611986 | 10.1111/irv.12915 | Early epidemiological investigations: World Health Organization UNITY protocols provide a standardized and timely international investigation framework during the COVID-19 pandemic. | 5 October 2021 00:00 | Journal Article | EG;US;CH;FR;IN;DK;PH;CG | en | WHO Health Emergencies Programme, World Health Organization Headquarters, Geneva, Switzerland.;Epidemiology Departement, Epiconcept, Paris, France.;Pan American Health Organization, Washington, D.C., USA.;World Health Organization for the Eastern Mediterranean, Cairo, Egypt.;Regional Office for South-East Asia, World Health Organization, New Delhi, India.;Regional Office for Africa, World Health Organization, Brazzaville, Republic of the Congo.;Regional Office for the Western Pacific, World Health Organization, Manila, Philippines.;Regional Office for Europe, World Health Organization, Copenhagen, Denmark. | The declaration of Coronavirus disease 2019 (COVID-19) as a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 required rapid implementation of early investigations to inform appropriate national and global public health actions. | Isabel Bergeri;Hannah C Lewis;Lorenzo Subissi;Anthony Nardone;Marta Valenciano;Brianna Cheng;Ketevan Glonti;Bridget Williams;Ibukun-Oluwa Omolade Abejirinde;Alice Simniceanu;Alessandro Cassini;Rebecca Grant;Angel Rodriguez;Andrea Vicari;Lubna Al Ariqi;Tasnim Azim;Pushpa Ranjan Wijesinghe;Soatiana Cathycia Rajatonirina;Joseph Chukwudi Okeibunor;Linh-Vi Le;Mark Katz;Aisling Vaughan;Pernille Jorgensen;Gudrun Freidl;Richard Pebody;Maria D Van Kerkhove | COVID-19;SARS-CoV-2;infectious diseases;seroepidemiology;serology;seroprevalence | [{"agency": "German Federal Ministry of Health (BMG) COVID-19 Research and Development for WHO", "country": ""}, {"agency": "COVID-19 Solidarity Response Fund for WHO", "country": ""}] | German Federal Ministry of Health (BMG) COVID-19 Research and Development for WHO;COVID-19 Solidarity Response Fund for WHO | pubmed | ||||
12 | 34609290 | 10.1684/pnv.2021.0951 | [How staff members of 17 French nursing homes protected their residents from Covid-19]. | 5 October 2021 00:00 | Journal Article | FR | fr | Service de gériatrie, Hôpital Charles Foix, Ivry-sur-Seine, France, Sorbonne Université, Faculté de Médecine, Paris, France. | Joël Belmin;Nathavy Um Din;Sylvie Pariel;Carmelo Lafuente-Lafuente | pubmed | ||||||||
13 | 34606578 | 10.1001/jama.2021.18178 | Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. | 4 October 2021 00:00 | Journal Article | CA;IE;US;NZ;TH;BE;JP;DE;NL;FR;CO;BR;AU;SG;SA;GB;LK | en | 0098-7484 | NHS Blood and Transplant, Oxford, England.;Radcliffe Department of Medicine and BRC Hematology Theme, University of Oxford, Oxford, England.;Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Université Laval, Quebec City, Quebec, Canada.;CHU de Québec-Université Laval Research Center, Population Health and Optimal Health Practices Unit, Trauma-Emergency-Critical Care Medicine, CHU de Québec-Université Laval, Quebec City, Quebec, Canada.;Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.;Department of Clinical Hematology, Monash Health, Melbourne, Australia.;Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.;Division of Anesthetics, Pain Medicine, and Intensive Care Medicine, Department of Surgery and Cancer, Imperial College London and Imperial College Healthcare NHS Trust, London, England.;Intensive Care Unit, Raymond Poincaré Hospit | JAMA | The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive. | Lise J Estcourt;Alexis F Turgeon;Zoe K McQuilten;Bryan J McVerry;Farah Al-Beidh;Djillali Annane;Yaseen M Arabi;Donald M Arnold;Abigail Beane;Philippe Bégin;Wilma van Bentum-Puijk;Lindsay R Berry;Zahra Bhimani;Janet E Birchall;Marc J M Bonten;Charlotte A Bradbury;Frank M Brunkhorst;Meredith Buxton;Jeannie L Callum;Michaël Chassé;Allen C Cheng;Matthew E Cove;James Daly;Lennie Derde;Michelle A Detry;Menno De Jong;Amy Evans;Dean A Fergusson;Matthew Fish;Mark Fitzgerald;Claire Foley;Herman Goossens;Anthony C Gordon;Iain B Gosbell;Cameron Green;Rashan Haniffa;Heli Harvala;Alisa M Higgins;Thomas E Hills;Veronica C Hoad;Christopher Horvat;David T Huang;Cara L Hudson;Nao Ichihara;Emma Laing;Abigail A Lamikanra;François Lamontagne;Patrick R Lawler;Kelsey Linstrum;Edward Litton;Elizabeth Lorenzi;Sheila MacLennan;John Marshall;Daniel F McAuley;John F McDyer;Anna McGlothlin;Shay McGuinness;Gail Miflin;Stephanie Montgomery;Paul R Mouncey;Srinivas Murthy;Alistair Nichol;Rachael Parke;Jane C Parker;Ni | pubmed | |||||
14 | 34607791 | 10.1136/annrheumdis-2021-221097 | BNT162b2 vaccine-induced humoral and cellular responses against SARS-CoV-2 variants in systemic lupus erythematosus. | 4 October 2021 00:00 | Journal Article | FR;US | en | 0003-4967,1468-2060 | Inserm, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Université, Paris, France.;Assistance Publique-Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière (GHPS), French National Reference Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Sorbonne Université, Paris, France.;Assistance Publique Hôpitaux de Paris (AP-HP), Département d'Immunologie, Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France.;Virology Department, Institut Pasteur-TheraVectys Joint Lab, Paris, France.;Unité de Virologie Moléculaire et Vaccinologie, Institut Pasteur, Paris, France.;Assay Development Department, Genalyte Inc, San Diego, California, USA.;Mathématiques appliquées, Sorbonne Universite Faculte des Sciences et Ingenierie, Paris, France.;Inserm, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Université, Paris, France zahir.amour | Annals of the Rheumatic Diseases | Our aim was to evaluate systemic lupus erythematosus (SLE) disease activity and SARS-CoV-2-specific immune responses after BNT162b2 vaccination. | Quentin Moyon;Delphine Sterlin;Makoto Miyara;François Anna;Alexis Mathian;Raphael Lhote;Pascale Ghillani-Dalbin;Paul Breillat;Sasi Mudumba;Sophia de Alba;Fleur Cohen-Aubart;Julien Haroche;Micheline Pha;Thi Huong Du Boutin;Hedi Chaieb;Pedro Macedo Flores;Pierre Charneau;Guy Gorochov;Zahir Amoura | COVID-19;lupus erythematosus;systemic;vaccination | pubmed | ||||
15 | 34604946 | 10.1007/s12124-021-09659-z | Sinophobia during the Covid-19 Pandemic: Identity, Belonging, and International Politics. | 4 October 2021 00:00 | Journal Article | FR | en | 1932-4502,1936-3567 | Department of Psychology, Health and Gender, The American University of Paris, Paris, France. zgao@aup.edu. | Integrative Psychological and Behavioral Science | In many countries, Sinophobia or discrimination against Chinese has taken place amid the Covid-19 pandemic. While this wave of Sinophobia is popularly understood to be based on a stereotypical association of Chinese with coronavirus, I argue that at a time of international tensions surrounding China, political antipathy toward China and Chinese matters as well. Thus, there is a phenomenon of "triple conflation" in which the health, racial, and political/national statuses of Chinese people become intermingled. In this study, I examine this triple conflation based on dozens of select cases covering Sinophobic actions of governments, politicians, media, businesses and lay persons in North America, Australia, New Zealand, and Western Europe. My study consists of three parts using three respective interdisciplinary approaches. First, using a sociological approach, I argue that the racial and national statuses of Chinese are both, and sometimes interchangeably, used as identity markers for i | Zhipeng Gao | Belonging;Chinese;Covid-19;Health;Identity;Politics;Racism | [{"grantid": "756-2019-0092", "agency": "Social Sciences and Humanities Research Council of Canada", "country": ""}] | Social Sciences and Humanities Research Council of Canada | pubmed | ||
16 | 34604983 | 10.5603/imh.2021.0031 | Management of COVID-19 on board the mixed cargo ship Aranui 5. | 4 October 2021 00:00 | Journal Article | FR | en | 2081-3252,1641-9251 | Faculty of Medicine Jacques Lisfranc, University Lyon-Saint-Etienne, France. chatard@univ-st-etienne.fr.;Health Simulation Centre of Scorff, Group, C3S-Groupe Hospitalier of Bretagne sud, Lorient, France.;Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.;Medical Department of Aranui 5, Raiatéa, French Polynesia.;Assistance Publique Hôpitaux de Marseille, Marseille, France. | International Maritime Health | During cruises, the management of coronavirus disease 2019 (COVID-19) infections poses serious organizational problems such as those encountered in 2020 by the Zaandam, the aircraft carrier Charles de Gaulle or the Diamond Princess. In French Polynesia, the mixed cargo ship Aranui 5 transports both tourists and freight to the Marquesas Islands. The purpose of this article is to show how COVID-19 infections were diagnosed and contained before and after passengers boarded a cruise. | Jean-Claude Chatard;Jean-Marc Le Gac;Sylvie Gonzalo;Philippe Vaysse;Mathieu Coulange | French Polynesia;crew members;cruise;rapid antigenic diagnostic orientation tests;reverse transcriptase-polymerase chain reaction (RT-PCR);virus infection | pubmed | ||||
17 | 34607874 | 10.1136/bmjopen-2021-055148 | Quantifying healthcare and welfare sector workers' preferences around COVID-19 vaccination: a cross-sectional, single-profile discrete-choice experiment in France. | 4 October 2021 00:00 | Journal Article | FR | en | 2044-6055,2044-6055 | Department of Quantitative Methods in Public Health, EHESP French School of Public Health, Paris and Rennes, La Plaine St Denis, France.;LIRAES (EA4470), University of Paris, Paris, France.;Research Group for the Prevention of Occupational Infections in Healthcare Workers (GERES), Paris, France.;Emerging Infectious Disease Epidemiology Unit, Institut Pasteur, Paris, France.;Prevention and Health Promotion, Santé publique France, Saint-Maurice, France.;Department of Infectious Diseases, University Hopital of Saint-Etienne, Saint-Etienne, France.;Chaire PreVacCI, Institut PRESAGE, University Jean Monnet University, Lyon University, Saint-Etienne, France.;Department of Quantitative Methods in Public Health, EHESP French School of Public Health, Paris and Rennes, La Plaine St Denis, France judith.mueller@ehesp.fr. | BMJ Open | To analyse preferences around promotion of COVID-19 vaccination among workers in the healthcare and welfare sector in Fance at the start of the vaccination campaign. | Carolina Díaz Luévano;Jonathan Sicsic;Gerard Pellissier;Sandra Chyderiotis;Pierre Arwidson;Cyril Olivier;Amandine Gagneux-Brunon;Elisabeth Botelho-Nevers;Elisabeth Bouvet;Judith Mueller | COVID-19;infectious diseases;public health | pubmed | ||||
18 | 34608263 | 10.1038/s41380-021-01309-5 | The acid sphingomyelinase/ceramide system in COVID-19. | 4 October 2021 00:00 | Journal Article;Review | DE;FR;US;GB | en | 1359-4184,1476-5578 | Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany. johannes.kornhuber@uk-erlangen.de.;AP-HP.Centre - Université de Paris, Département Médico-Universitaire de Psychiatrie et Addictologie, Hôpital Corentin-Celton, 92130, Issy-les-Moulineaux, France.;INSERM, Institut de Psychiatrie et Neurosciences de Paris, UMR_S1266, Paris, France.;Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.;Department of Surgery, University of Cincinnati, Cincinnati, OH, USA. | Molecular Psychiatry | Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide, which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS-CoV-2 uses these platforms for cell entry. Lowering the amount of ceramide or ceramide blockade due to inhibitors of ASM, genetic downregulation of ASM, anti-ceramide antibodies or degradation by neutral ceramidase protected against infection with SARS-CoV-2. The addition of ceramide restored infection with SARS-CoV-2. Many clinically approved medications functionally inhibit ASM and are called FIASMAs (functional inhibitors of acid sphingomyelinase). The FIASMA fluvoxamine showed beneficial effects on COVID-19 in a randomized prospective study and a prospective open-label real-world study. Retrospective and observational studies showed favorable effects of FIASMA antidepressants including fluoxetine, and the FIASMA hydroxyzine on the course of COVID-19. The ASM/ceramide system provides a framework for a better und | Johannes Kornhuber;Nicolas Hoertel;Erich Gulbins | pubmed | |||||
19 | 34608167 | 10.1038/s41467-021-26096-z | Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection. | 4 October 2021 00:00 | Journal Article | IT;FR;US | en | 2041-1723 | CIRI, Centre International de Recherche en Infectiologie, Team Immunobiology of the Viral infections, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, LYON, France. marion.ferren@inserm.fr.;CIRI, Centre International de Recherche en Infectiologie, Team Immunobiology of the Viral infections, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, LYON, France.;Département du Rhône, Lyon, France.;Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USA.;Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258, CNRS UMR 7104, Université de Strasbourg, Illkirch, France.;CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, LYON, France.;Center for Host-Pathogen Interaction, Columbia University | Nature Communications | SARS-CoV-2 has caused a global pandemic of COVID-19 since its emergence in December 2019. The infection causes a severe acute respiratory syndrome and may also spread to central nervous system leading to neurological sequelae. We have developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offer a unique opportunity to study the early steps of viral infection and screening antivirals. These models are not dedicated to investigate how the virus reaches the brain. However, they allow validating the early tropism of the virus in the lungs and demonstrating that SARS-CoV-2 could infect the brainstem and the cerebellum, mainly by targeting granular neurons. Viral infection induces specific interferon and innate immune responses with patterns specific to each organ, along with cell death by apoptosis, necroptosis, and pyroptosis. Overall, our data illustrate the potential of rapid modeling of complex tissue-level interactions during infection by | Marion Ferren;Valérie Favède;Didier Decimo;Mathieu Iampietro;Nicole A P Lieberman;Jean-Luc Weickert;Rodolphe Pelissier;Magalie Mazelier;Olivier Terrier;Anne Moscona;Matteo Porotto;Alexander L Greninger;Nadia Messaddeq;Branka Horvat;Cyrille Mathieu | [{"grantid": "ANR-20-COVI-000", "agency": "Fondation de France", "country": ""}, {"grantid": "GloPID-COVID-19 (ANRS-COV08_ SARSRhinCell)", "agency": "Agence Nationale de Recherches sur le Sida et les Hépatites Virales (National Agency for AIDS Research)", "country": ""}] | Fondation de France;Agence Nationale de Recherches sur le Sida et les Hépatites Virales (National Agency for AIDS Research) | pubmed | |||
20 | 34605990 | 10.1007/s00586-021-07007-8 | Effects of COVID-19 lockdown on low back pain intensity in chronic low back pain patients: results of the multicenter CONFI-LOMB study. | 4 October 2021 00:00 | Journal Article | FR;CH | en | 0940-6719,1432-0932 | Pain Unit, Rheumatology Department, Pitié Salpêtrière Hospital, AP-HP, 47-83 boulevard de l'hôpital, 75013, Paris, France.;Division of Rheumatology, Beau Sejour Hospital, Geneva University Hospitals, 14, CH-1205, Geneva, Switzerland.;Rheumatology Department, Pitié Salpêtrière Hospital, AP-HP, 47-83 boulevard de l'hôpital, 75013, Paris, France.;Rheumatology Department, Dijon University Hospital, 14 rue Gaffarel, 21000, Dijon, France.;Rheumatology Practice, 17 Boulevard Agutte Sembat, 38000, Grenoble, France.;Pain, Palliative and Supportive Care Department, University Hospital of Nantes, 1 Place Alexis-Ricordeau, 44093, Nantes, France.;University of Angers, Inserm, EHESP, Irset, UMR-S 1085, Angers, France. aupetit@chu-angers.fr.;Department of Occupational Medecine, University Hospital of Angers, 4 rue Larrey, 49933, Angers cedex 9, France. aupetit@chu-angers.fr. | European Spine Journal | The COVID-19 pandemic and the extended lockdown are associated with numerous changes in behavior and lifestyles. The objective was to assess the impact of the first lockdown on LBP course among chronic LBP patients. | Florian Bailly;Stéphane Genevay;Violaine Foltz;Amélie Bohm-Sigrand;Alain Zagala;Julien Nizard;Audrey Petit | COVID-19;Lockdown experience;Low back pain;Physical activity | pubmed | ||||
21 | 34614444 | 10.1016/j.ijid.2021.09.079 | Persistent IgG anti-cardiolipin autoantibodies are associated with post-covid syndrome. | 3 October 2021 00:00 | Case Reports | FR | en | 1201-9712 | Service d'Immunologie, Pôle de Biologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), France. Electronic address: daniel.bertin@ap-hm.fr.;Service de Neurologie, Pôle de Neurosciences Cliniques, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France.;Service d'Immunologie, Pôle de Biologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), France.;Service de Médecine Interne et d'Immunologie Clinique, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), France, Aix Marseille Université, C2VN, INSERM UMR_S 1263, Marseille, France.;Service de Médecine Interne, Aix-Marseille Université, AP-HM, Hôpital La Timone, Marseille, France.;Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille (AP-HM), Aix Marseille Université, Marseille, France.;Service d'Immunologie, Pôle de Biologie, Hôpital de la Conception, Assist | International Journal of Infectious Diseases | Persistence of various symptoms in patients who recovered from COVID-19 was recently defined as long COVID or post-COVID syndrome (PCS). We report a case of a 58-year-old woman who, although recovering from COVID-19, has novel and persistent symptoms such as neurological complications, not explained by another cause apart from PCS. In addition to a low inflammatory response, we found a persistence of IgG aCL positivity and eosinopenia, one year after the COVID-19 acute infection, both previously defined as independent factors associated with disease severity. The pathophysiological mechanism of PCS is not known, but the possibility of persistence of the virus, especially in the nervous system, could be suggested, with a post-infectious inflammatory or autoimmune reaction. | Daniel Bertin;Elsa Kaphan;Samuel Weber;Benjamin Babacci;Robin Arcani;Benoit Faucher;Amélie Ménard;Alexandre Brodovitch;Jean Louis Mege;Nathalie Bardin | pubmed | |||||
22 | 34599096 | 10.1073/pnas.2102565118 | The impact of social isolation and changes in work patterns on ongoing thought during the first COVID-19 lockdown in the United Kingdom. | 2 October 2021 00:00 | Journal Article;Research Support, Non-U.S. Gov't | CA;FR;GB | en | 0027-8424,1091-6490 | Department of Psychology, University of York, York, YO10 5DD, United Kingdom, bronte.mckeown@york.ac.uk.;Department of Psychology, University of Essex, Colchester, CO4 3SQ, United Kingdom.;Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PX, United Kingdom.;Laboratoire de Psychologie Cognitive et Sociale, CNRS UMR 6024, Université Clermont Auvergne, 63000 Clermont-Ferrand, France.;Department of Psychology, Northumbria University, Newcastle upon Tyne, NE1 8ST, United Kingdom.;Department of Psychology, University of York, York, YO10 5DD, United Kingdom.;Psychology Department, Queen's University, Kingston, Ontario, K7L 3N6, Canada. | Proceedings of the National Academy of Sciences | The COVID-19 pandemic led to lockdowns in countries across the world, changing the lives of billions of people. The United Kingdom's first national lockdown, for example, restricted people's ability to socialize and work. The current study examined how changes to socializing and working during this lockdown impacted ongoing thought patterns in daily life. We compared the prevalence of thought patterns between two independent real-world, experience-sampling cohorts, collected before and during lockdown. In both samples, young (18 to 35 y) and older (55+ y) participants completed experience-sampling measures five times daily for 7 d. Dimension reduction was applied to these data to identify common "patterns of thought." Linear mixed modeling compared the prevalence of each thought pattern 1) before and during lockdown, 2) in different age groups, and 3) across different social and activity contexts. During lockdown, when people were alone, social thinking was reduced, but on the rare occ | Brontë Mckeown;Giulia L Poerio;Will H Strawson;Léa M Martinon;Leigh M Riby;Elizabeth Jefferies;Cade McCall;Jonathan Smallwood | COVID-19;experience sampling;isolation;lockdown;thoughts | [{"agency": "European Research Council", "country": "International"}] | European Research Council | pubmed | ||
23 | 34601723 | 10.15252/embj.2021108944 | SARS-CoV-2 Alpha, Beta and Delta variants display enhanced Spike-mediated Syncytia Formation. | 2 October 2021 00:00 | Journal Article | FR | en | 0261-4189,1460-2075 | Virus & Immunity Unit, Department of Virology, Institut Pasteur, CNRS, UMR 3569, Paris, France.;Université de Paris, Sorbonne Paris Cité, Paris, France.;Vaccine Research Institute, Creteil, France.;Sorbonne Université, Paris, F-75005, France.;Integrative Neurobiology of Cholinergic Systems, Department of Neuroscience, Institut Pasteur, CNRS, UMR 3571, Paris, France.;Sorbonne Université, ED3C "Brain, cognition, behavior", Paris, France.;Laboratory of Humoral Immunology, Department of Immunology, Institut Pasteur, INSERM U1222, Paris, France. | The EMBO Journal | Severe COVID-19 is characterized by lung abnormalities, including the presence of syncytial pneumocytes. Syncytia form when SARS-CoV-2 spike protein expressed on the surface of infected cells interacts with the ACE2 receptor on neighbouring cells. The syncytia forming potential of spike variant proteins remain poorly characterized. Here, we first assessed Alpha (B.1.1.7) and Beta (B.1.351) spread and fusion in cell cultures, compared to the ancestral D614G strain. Alpha and Beta replicated similarly to D614G strain in Vero, Caco-2, Calu-3 and primary airway cells. However, Alpha and Beta formed larger and more numerous syncytia. Variant spike proteins displayed higher ACE2 affinity compared to D614G. Alpha, Beta and D614G fusion was similarly inhibited by interferon induced transmembrane proteins (IFITMs). Individual mutations present in Alpha and Beta spikes modified fusogenicity, binding to ACE2 or recognition by monoclonal antibodies. We further show that Delta spike also triggers f | Maaran Michael Rajah;Mathieu Hubert;Elodie Bishop;Nell Saunders;Remy Robinot;Ludivine Grzelak;Delphine Planas;Jérémy Dufloo;Stacy Gellenoncourt;Alice Bongers;Marija Zivaljic;Cyril Planchais;Florence Guivel-Benhassine;Françoise Porrot;Hugo Mouquet;Lisa A Chakrabarti;Julian Buchrieser;Olivier Schwartz | pubmed | |||||
24 | 34598702 | 10.1186/s12913-021-07084-x | Protocol refinement for a diabetes pragmatic trial using the PRECIS-2 framework. | 2 October 2021 00:00 | Clinical Trial Protocol;Journal Article | FR;US;GB | en | 1472-6963 | University of Colorado Anschutz Medical Campus, 13199 E Montview Blvd Ste 210, Aurora, CO, 80045, USA. Russell.Glasgow@CUAnschutz.edu.;VA Eastern Colorado QUERI and Geriatric Research Centers, 1055 Clermont St, Denver, CO, 80220, USA. Russell.Glasgow@CUAnschutz.edu.;University of Colorado Anschutz Medical Campus, 13199 E Montview Blvd Ste 210, Aurora, CO, 80045, USA.;Denver Health and Hospital Authority, 777 Bannock St, Denver, CO, 80204, USA. | BMC Health Services Research | Appointments and Schedules;COVID-19;Comparative Effectiveness Research;Diabetes Mellitus__therapy;Humans;SARS-CoV-2 | This report describes how we refined a protocol for a pragmatic comparative effectiveness study of two models of an evidence-based diabetes shared medical appointment intervention and used the PRECIS-2 rating system to evaluate these adaptations. | Russell E Glasgow;Dennis Gurfinkel;Jeanette Waxmonsky;Jenny Rementer;Natalie D Ritchie;Jennifer Dailey-Vail;Patrick Hosokawa;L Miriam Dickinson;Bethany M Kwan | Design;Implementation science;PRECIS-2;Planning;Pragmatic research;Shared medical appointments;Transparency;Type 2 diabetes | pubmed | |||
25 | 34611533 | 10.1016/j.dib.2021.107442 | Dataset of the Vascular e-Learning during the COVID-19 pandemic (EL-COVID) survey. | 1 October 2021 00:00 | Journal Article | PL;ES;IT;CN;GR;DE;BR;LB;ID;US;IR;HU;RO;UA;SG;GB;ZA;DZ;CA;RU;UY;HR;NL;FR;TR | en | 2352-3409 | 3rd Department of Vascular Surgery, Athens Medical Center, Greece.;National & Kapodistrian University of Athens, Greece.;Vascular surgery department, First affiliated hospital to Navy medical university, Shanghai, PR China.;Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany.;Faculty of Medicine University of Indonesia - Cipto Mangunkusumo National Hospital, Indonesia.;Federal University Fluminense, Brazil.;Centre Hospitalier de l'Université de Montréal, Canada.;Centre Hospitalier de Troyes, France.;Hotel Dieu de France Hospital, Lebanon.;University of the Witwatersrand, South Africa.;University of Medicine and Pharmacy, Romania.;Semmelweis University, Hungary.;Amsterdam University Medical Center, The Netherlands.;VU Medical Center, The Netherlands.;Paracelsus Medical University, Klinikum Nurenberg, Germany.;University of Pittsburgh Medical Center, USA.;Duke University Medical Center, USA.;National University of Singapore, Singapore.;University Hospita | Data in Brief | This dataset supports the findings of the vascular e-Learning during the COVID-19 pandemic survey (the EL-COVID survey). The General Data Protection Regulation (GDPR) of the European Union was taken into consideration in all steps of data handling. The survey was approved by the institutional ethics committee of the Primary Investigator and an online English survey consisting of 18 questions was developed ad-hoc. A bilingual English-Mandarin version of the questionnaire was developed according to the instructions of the Chinese Medical Association in order to be used in mainland People's Republic of China. Differences between the two questionnaires were minor and did affect the process of data collection. Both questionnaires were hosted online. The EL-COVID survey was advertised through major social media. All national and regional contributors contacted their respective colleagues through direct messaging on social media or by email. Eight national societies or groups supported the di | Nikolaos Patelis;Theodosios Bisdas;Zaiping Jing;Jiaxuan Feng;Matthias Trenner;Nyityasmono Nugroho;Paulo Eduardo Ocke Reis;Stephane Elkouri;Alexandre Lecis;Lamisse Karam;Dirk Le Roux;Mihai Ionac;Marton Berczeli;Vincent Jongkind;Kak Khee Yeung;Athanasios Katsargyris;Efthymios Avgerinos;Demetrios Moris;Andrew Choong;Jun Jie Ng;Ivan Cvjetko;George A Antoniou;Phil Ghibu;Alexei Svetlikov;Fernando Gallardo Pedrajas;Harm P Ebben;Hubert Stepak;Andrii Chornuy;Sviatoslav Kostiv;Stefano Ancetti;Niki Tadayon;Akli Mekkar;Leonid Magnitskiy;Liliana Fidalgo-Domingos;Sean Matheiken;Eduardo Sebastian Sarutte Rosello;Arda Isik;Georgios Kirkilesis;Kyriaki Kakavia;Sotirios Georgopoulos | distance learning;e-learning;education;surgery;training;vascular surgery | pubmed | ||||
26 | 34599047 | Case of Giant Cell Arteritis After SARS-CoV-2 Vaccination: A Particular Phenotype? | 1 October 2021 00:00 | Letter | FR | en | CHU Clermont-Ferrand, Service de Médecine Interne, Hôpital Gabriel Montpied, Université Clermont Auvergne, Inserm U1071, INRA USC2018, M2iSH, Clermont-Ferrand, France. The authors declare no conflicts of interest relevant to this article. Address correspondence Dr. L. Trefond, Médecine Interne, CHU Gabriel Montpied, 58, rue Montalembert 63000 Clermont Ferrand, France. Email: ludovic.trefond@chu-clermontferrrand.fr. | We read with great interest the article by Mehta et al about the similarities and discriminators between giant cell arteritis (GCA) and the coronavirus disease 2019 (COVID-19).1 Viruses have been suspected to be implicated in the pathogenesis of GCA, especially the varicella zoster virus,2 but a clear association has not been confirmed.3. | Agathe Sauret;Julien Stievenart;Perrine Smets;Louis Olagne;Benedicte Guelon;Olivier Aumaître;Marc André;Ludovic Trefond | pubmed | ||||||||
27 | 34607080 | Comparison of the first and second waves of coronavirus disease in Toulouse, France. | 1 October 2021 00:00 | Letter | FR | en | Service des maladies infectieuses et tropicales, CHU de Toulouse Purpan, Place du Dr Joseph Baylac, 31300 Toulouse, France. Electronic address: jourdes.a@chu-toulouse.fr.;Centre d'investigation clinique 1436, CHU de Toulouse Purpan, Place du Dr Joseph Baylac, 31300 Toulouse, France, Service de pharmacologie médicale et technique, CHU de Toulouse, 37 allées Jules Guesde, 31000 Toulouse, France.;Service de médecine interne, CHU de Toulouse Purpan, Place du Dr Joseph Baylac, 31300 Toulouse, France.;Service des maladies infectieuses et tropicales, CHU de Toulouse Purpan, Place du Dr Joseph Baylac, 31300 Toulouse, France.;Service de radiologie et imagerie médicale, CHU de Toulouse Purpan, Place du Dr Joseph Baylac, 31300 Toulouse, France. | A Jourdes;M Lafaurie;G Moulis;P Delobel;M Faruch;A Sommet;G Martin-Blondel | COVID-19;Epidemiology;SARS-CoV-2 | pubmed | ||||||||
28 | 34595810 | Neutralizing antibodies directed against SARS-CoV-2 in a population residing in a nursing home and a long-term care unit. | 1 October 2021 00:00 | Letter | FR | en | Department of Gerontology, Amiens University Hospital, Amiens, France.;AGIR Research Unit, UR UPJV 4294, Jules Verne University of Picardie, Amiens, France.;Department of Immunology, Amiens University Hospital, Amiens, France.;HEMATIM - EA4666, Jules Verne University of Picardie, Amiens, France.;Infectious Diseases Department, Amiens University Hospital, Amiens, France.;Department of Molecular Oncobiology, Amiens University Hospital, Amiens, France.;Department of Virology, Amiens University Hospital, Amiens, France.;Laboratory of Functional Neurosciences UR 4559, Jules Verne University of Picardie, Amiens, France. | Julien Moyet;Francois Helle;Gwladys Bourdenet;Cédric Joseph;Brigitte Gubler;Etienne Brochot;Frédéric Bloch | [{"agency": "AGIPI", "country": ""}] | AGIPI | pubmed | |||||||
29 | 34598278 | 10.1093/cid/ciab868 | Persistent COVID-19 in an immunocompromised host treated by SARS-CoV-2-specific monoclonal antibodies. | 1 October 2021 00:00 | Journal Article | FR;US | en | 1058-4838,1537-6591 | Service de maladies infectieuses, Centre hospitalier universitaire de Besançon, Besançon, France.;Service de maladies infectieuse, Centre hospitalier Jura Sud, Lons le Saunier, France.;Centre de Recherche des Cordeliers, INSERM, Université Sorbonne Paris Cité, Université de Paris, UMRS, Equipe FunGest, Paris, France.;Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.;Service d'hématologie, Centre hospitalier universitaire de Besançon, Besançon, France.;Service de pneumologie, Centre hospitalier universitaire de Besançon, Besançon, France.;Service d'hématologie adulte, Hôpital Necker, Institut Imagine, INSERM U 1163, Université de Paris, Assistance Publique-Hôpitaux de Paris, Paris, France.;Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, France.;Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U 1163, Necker Hospital for Sick Children | Clinical Infectious Diseases | Benoit Bailly;Helene Péré;David Veyer;Ana Berceanu;Etienne Daguindau;Pauline Roux;Olivier Hermine;Xavier de Lamballerie;Paul Bastard;Karine Lacombe;Brigitte Autran;Fanny Angelot Delettre;Jean Laurent Casanova;Sandrine Imbeaud;Anne Laure Clairet;Marie Kroemer;Laurie Spehner;Nicolas Robillard;Julien Puech;Solène Marty-Quinternet;Quentin Lepiller;Catherine Chirouze;Kevin Bouiller | pubmed | ||||||
30 | 34605777 | 10.1097/ccm.0000000000005374 | Coronavirus Disease 2019 and Out-of-Hospital Cardiac Arrest: No Survivors. | 1 October 2021 00:00 | Journal Article | FR | en | 0090-3493 | University of Lille, CHU Lille, ULR 2694 - METRICS: Évaluation des technologies de santé et des pratiques médicales, F-59000, Lille, France. French National Out-of-Hospital Cardiac Arrest Registry, Lille, France. Department of Emergency Medicine, Nantes University Medical Center and University of Nantes, Microbiotas Hosts Antibiotics and bacterial Resistances (MiHAR), University of Nantes, Nantes, France. SAMU 69, Edouard Herriot Hospital, Lyon University Medical Center, Lyon, France. Assistance Publique - Hôpitaux de Paris (AP-HP), Henri Mondor University Hospital, SAMU 94, Créteil, France. SAMU 59, Dron Hospital, Tourcoing, France. | Critical Care Medicine | To describe and compare survival among patients with out-of-hospital cardiac arrest as a function of their status for coronavirus disease 2019. | Valentine Baert;Jean-Baptiste Beuscart;Morgan Recher;François Javaudin;Delphine Hugenschmitt;Thomas Bony;François Revaux;Nadia Mansouri;Fanny Larcher;Emmanuel Chazard;Hervé Hubert | pubmed | |||||
31 | 33979992 | 10.3324/haematol.2021.278573 | Low incidence of COVID-19 severe complications in a large cohort of children with sickle cell disease: a protective role for basal interferon-1 activation? | 1 October 2021 00:00 | Journal Article | FR | en | 1592-8721,0390-6078 | Sickle Cell Disease Center, Hematology Unit, Hôpital Robert Debré, Assistance Publique - Hôpitaux de Paris, F-75019 Paris, France, Université de Paris, UMR_S1134, BIGR, INSERM, Institut National de la Transfusion Sanguine, Laboratoire d'Excellence GR-Ex, F-75015 Paris.;Sickle Cell Disease Center, Hematology Unit, Hôpital Robert Debré, Assistance Publique - Hôpitaux de Paris, F-75019 Paris.;CIRI, Centre International de Recherche en Infectiologie, Université Lyon 1, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS, F-69100 Lyon, France, Laboratoire d'Immunologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, F- 69310 Pierre-Bénite.;Université de Paris, Assistance Publique - Hôpitaux de Paris, Service de virologie, Hôpital Bichat, INSERM UMR 1137-IAME, DeSCID: Decision SCiences in Infectious Diseases control and care, F-75018 Paris.;Université de Paris, UMR_S1134, BIGR, INSERM, Institut National de la Transfusion Sanguine, Laboratoire d'Excellence GR-Ex, F-75015 | Haematologica | Anemia, Sickle Cell__complications;COVID-19;Child;Humans;Incidence;Interferons;SARS-CoV-2 | Valentine Brousse;Laurent Holvoet;Rémi Pescarmona;Sebastien Viel;Magali Perret;Benoit Visseaux;Valentine Marie Ferre;Ghislaine Ithier;Caroline Le Van Kim;Malika Benkerrou;Florence Missud;Berengere Koehl | pubmed | |||||
32 | 34606831 | 10.1016/j.jmb.2021.167280 | The mechanism and consequences of SARS-CoV-2 spike-mediated fusion and syncytia formation. | 1 October 2021 00:00 | Journal Article;Review | FR | en | 0022-2836 | Virus & Immunity Unit, Department of Virology, Institut Pasteur, CNRS UMR 3569, Paris, France, Université de Paris, Sorbonne Paris Cité, Paris, France.;Institut Curie, INSERM U932, Paris, France.;Virus & Immunity Unit, Department of Virology, Institut Pasteur, CNRS UMR 3569, Paris, France.;Virus & Immunity Unit, Department of Virology, Institut Pasteur, CNRS UMR 3569, Paris, France, Université de Paris, Sorbonne Paris Cité, Paris, France, Vaccine Research Institute, Creteil, France. Electronic address: olivier.schwartz@pasteur.fr. | Journal of Molecular Biology | Syncytia are formed when individual cells fuse. SARS-CoV-2 induces syncytia when the viral spike (S) protein on the surface of an infected cell interacts with receptors on neighboring cells. Syncytia may potentially contribute to pathology by facilitating viral dissemination, cytopathicity, immune evasion, and inflammatory response. SARS-CoV-2 variants of concern possess several mutations within the S protein that enhance receptor interaction, fusogenicity and antibody binding. In this review, we discuss the molecular determinants of S mediated fusion and the antiviral innate immunity components that counteract syncytia formation. Several interferon-stimulated genes, including IFITMs and LY6E act as barriers to S protein-mediated fusion by altering the composition or biophysical properties of the target membrane. We also summarize the effect that the mutations associated with the variants of concern have on S protein fusogenicity. Altogether, this review contextualizes the current unde | Maaran Michael Rajah;Annie Bernier;Julian Buchrieser;Olivier Schwartz | pubmed | |||||
33 | 34599556 | 10.1111/coa.13870 | Single nucleotide polymorphism in chronic rhinosinusitis: a systematic review. | 1 October 2021 00:00 | Journal Article;Review | ES;IT;BE;FR;BG | en | 1749-4478,1749-4486 | Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", ENT Section, ENT Department of University of Catania, Via Santa Sofia, 95100, Catania, Italy.;Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95125, Catania, Italy.;Research Committee of the Young Otolaryngologists, International Federations of ORL Societies, Paris, France.;Department of Human Anatomy and Experimental Oncology, School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons, Mons, Belgium.;Department of Otorhinolaryngology-Head and Neck Surgery, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.;Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, (University of Paris-Saclay), Paris, France.;Medical Molecular Microbiology and Antibiotic Resistance Laboratory (MMARLab), Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, | Clinical Otolaryngology | We performed a systematic review on single nucleotide polymorphisms and risk-related chronic rhinosinusitis. | Antonino Maniaci;Nicola Musso;Jerome Renee Lechien;Federico Merlino;Chiara Viglianisi;Stefano Stracquadanio;Maria Santagati;Salvatore Cocuzza;Antonio Bonanno;Christian Calvo-Henriquez;Stefani Stefania;Ignazio La Mantia | Chronic rhinosinusitis;Polymorphism;SNP;Sequencing;metagenomics | pubmed | ||||
34 | 34596318 | 10.1002/alz.12472 | Commentary: Global Alzheimer's disease and Alzheimer's disease related dementia research funding organizations support and engage the research community throughout the COVID-19 pandemic. | 1 October 2021 00:00 | Journal Article | US;CZ;DE;FR;GB | en | 1552-5260,1552-5279 | Medical & Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.;Fondation Alzheimer, Paris, France.;BrightFocus Foundation, Clarksburg, Maryland, USA.;Fondation Vaincre Alzheimer, Paris, France.;Alzheimer's Drug Discovery Foundation, New York, New York, USA.;Alzheimer's Society UK, London, UK.;Czech Alzheimer Foundation, Prague, Czech Republic.;Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.;Alzheimer's Research UK, Cambridge, UK.;Alzheimer Forschung Initiative, Düsseldorf, Germany.;Alzheimer's Disease International, London, UK. | Alzheimer's & Dementia | The COVID-19 pandemic has disproportionately affected more vulnerable populations, including those living with dementia. Over 50 million individuals worldwide are living with Alzheimer's disease (AD) or other dementia, and it is crucial to continue the fight against the condition during the global pandemic. Since the start of mandated lockdowns in March 2020, charity and non-profit organizations that fund AD and related dementia research continue to respond to the needs of the AD research community, ensuring the momentum continues and accelerates. Members of the International Alzheimer's and Related Dementia Research Funder Consortium, a group of nearly 40 funding organizations that informally convene throughout the year to share updates and information, have taken a number of steps to ensure the continued support of the research community. Even during times of uncertainty, it is essential that the field moves forward to uncover preventions, diagnoses, and treatments for these diseases | Emily A Meyers;Philippe Amouyel;Diane E Bovenkamp;Maria C Carrillo;Geraldine Drexel De Buchy;Magali Dumont;Howard Fillit;Lauren Friedman;Gregor Henderson-Begg;Jakub Hort;Andrew Murtishaw;Richard Oakley;Maï Panchal;Sharyn L Rossi;Rosa M Sancho;Linda Thienpont;Wendy Weidner;Heather M Snyder | Alzheimer's disease;COVID-19;dementia;nonprofit;public health;research funding | pubmed | ||||
35 | 34607001 | 10.1016/j.cmi.2021.09.034 | Corrigendum to 'Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives' [Clinical Microbiology and Infection 27/5 (2021) 789-790]. | 1 October 2021 00:00 | Published Erratum | FR | en | 1198-743X | Université de Paris, IAME, INSERM, Paris, France, Virology, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, Paris, France.;Université de Paris, IAME, INSERM, Paris, France, Virology, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, Paris, France. Electronic address: benoit.visseaux@aphp.fr.;Université de Paris, IAME, INSERM, Paris, France, Centre for Clinical Investigation, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, Paris, France.;Université de Paris, IAME, INSERM, Paris, France, Medical and Infectious Diseases Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, Paris, France.;Université de Paris, IAME, INSERM, Paris, France, Tropical and infectious diseases Department, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, Paris, France.;Virology, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bern | Clinical Microbiology and Infection | Quentin Le Hingrat;Benoit Visseaux;Cédric Laouenan;Sarah Tubiana;Lila Bouadma;Yazdan Yazdanpanah;Xavier Duval;Charles Burdet;Houria Ichou;Florence Damond;Mélanie Bertine;Nabil Benmalek;Christophe Choquet;Jean-François Timsit;Jade Ghosn;Charlotte Charpentier;Diane Descamps;Nadhira Houhou-Fidouh | pubmed | ||||||
36 | 34606914 | Reply Prognosis of Covid-19 patients with chronic liver disease in France in 2020. | 1 October 2021 00:00 | Letter | FR | en | AP-HP.Centre Université de Paris, Groupe Hospitalier Cochin Port Royal, DMU Cancérologie et spécialités médico-chirurgicales, Service d'Hépatologie, Paris, France. Electronic address: vincent.mallet@aphp.fr.;Department of methodology and innovation in prevention, Bordeaux university hospital, 33000 Bordeaux, France, University of Bordeaux, Inserm UMR 1219-Bordeaux Population Health, 33000 Bordeaux, France. | Vincent Mallet;Michaël Schwarzinger | pubmed | |||||||||
37 | 34611543 | 10.1016/j.ssmph.2021.100936 | Depressive symptoms in higher education students during the first wave of the COVID-19 pandemic. An examination of the association with various social risk factors across multiple high- and middle-income countries. | 1 October 2021 00:00 | Journal Article | US;CH;BE;GR;DE;NL;FR;TR;GB | en | 2352-8273 | Centre for Population, Family and Health, Department of Sociology, University of Antwerp, Sint-Jacobsstraat 2-4, 2000, Antwerpen, Belgium.;Student Health Services, University of Amsterdam, the Netherlands.;Department of Psychology, Middle East Technical University, Üniversiteler Mahallesi, Dumlupınar Bulvarı No:1, 06800, Çankaya/Ankara, Turkey.;Health & Demographic Research, Department of Sociology, Ghent University, Korte Meer 5, 9000, Gent, Belgium.;Institute of Social and Preventive Medicine, Faculty of Medicine, Universität Bern, Mittelstrasse 43, 3012, Bern, Switzerland.;Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstraße 30, 28213, Bremen, Germany.;School of Health Sciences, Faculty of Health, Education & Life Sciences, Birmingham City University, Westbourne Road, Birmingham, B15 3TN, UK.;National Centre for Social Research, 9 Kratinou & Athinas St., 10552, Athens, Greece.;Department of Social Medicine, University of Antwerp, Universiteitsplein 1, 2610 | SSM - Population Health | Higher-education students face substantial risks for developing depressive symptoms during the COVID-19 pandemic or experiencing exacerbated pre-existing depressive symptoms. This study uses data from the COVID-19 International Student Well-Being Study, which collected data through a non-representative convenience sample in 125 higher-education institutions (HEI) across 26 high- and middle-income countries (N: 20,103) during the first wave of the COVID-19 pandemic. It describes the prevalence of depressive symptoms in higher-education students. We find substantial cross-national variation in depressive symptoms, with lowest mean levels established in the Nordic countries and France, while highest mean levels of depressive symptoms were found in Turkey, South Africa, Spain and the USA. Elevated risk for depressive symptoms was found in female students, students with fewer social support resources and in a more disadvantaged socioeconomic position, and students with a migrant background. | S Van de Velde;V Buffel;C van der Heijde;S Çoksan;P Bracke;T Abel;H Busse;H Zeeb;F Rabiee-Khan;T Stathopoulou;G Van Hal;J Ladner;M Tavolacci;R Tholen;E Wouters | COVID-19;Depressive symptoms;Higher education students | pubmed | ||||
38 | 34607078 | Antenatal telehealth for anaesthesia consultations at the time of lockdown during the first Covid-19 wave in Paris. | 1 October 2021 00:00 | Letter | UNK;FR | en | Service d'Anesthésie Réanimation Médecine Péri Opératoire, AP-HP. Université Paris Saclay, Hôpital Bicêtre. Electronic address: dan.benhamou@aphp.fr.;Service d'Anesthésie Réanimation Médecine Péri Opératoire, Centre hospitalier intercommunal de Villeneuve Saint-Georges.;Service d'Anesthésie Réanimation Médecine Péri Opératoire, AP-HP. Hôpital Pitié Salpétrière, Paris.;Service d'Anesthésie Réanimation Médecine Péri Opératoire, AP-HP. Hôpital Robert Debré, Paris.;Service d'Anesthésie Réanimation Médecine Péri Opératoire, AP-HP. Hôpital Bichat, Paris.;Service d'Anesthésie Réanimation Médecine Péri Opératoire, AP-HP. Hôpital Antoine Béclère, Paris. | Dan Benhamou;Rania Miled;Gerard Corsia;Anne-Laure Horlin;Elie Kantor;Agnès Legouez;Patricia Medioni | Covid-19;anaesthesia;pre-anaesthesia consultation;telehealth | pubmed | ||||||||
39 | 34599175 | 10.1038/s41467-021-26055-8 | Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions. | 1 October 2021 00:00 | Journal Article | CD;CA;IT;GN;LT;CF;CH;BE;GQ;DE;NL;FR;SE;CM;DK;GB | en | 2041-1723 | Gothenburg Global Biodiversity Centre, Gothenburg, Sweden. gytisdudas@gmail.com.;Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania. gytisdudas@gmail.com.;Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.;Epidemiology of Highly Pathogenic Organisms, Robert Koch Institute, 13353, Berlin, Germany.;Viral Evolution, Robert Koch Institute, 13353, Berlin, Germany.;WWF Central African Republic Programme Office, Dzanga Sangha Protected Areas, BP 1053, Bangui, Central African Republic.;Infectious and Tropical Diseases Unit, Department of medicine, Amitié Hospital, Bangui, Central African Republic.;Academic Department of Pediatrics, Clinical immunology and vaccinology, Children's Hospital Bambino Gesù, IRCCS, Rome, Italy.;BlueDot, Toronto, ON, M5J 1A7, Canada.;Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, M5B 1A6, Canada.;Division of Infectious Diseas | Nature Communications | Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Δ, Y144Δ, and LLA241/243Δ. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected tr | Gytis Dudas;Samuel L Hong;Barney I Potter;Sébastien Calvignac-Spencer;Frédéric S Niatou-Singa;Thais B Tombolomako;Terence Fuh-Neba;Ulrich Vickos;Markus Ulrich;Fabian H Leendertz;Kamran Khan;Carmen Huber;Alexander Watts;Ingrida Olendraitė;Joost Snijder;Kim N Wijnant;Alexandre M J J Bonvin;Pascale Martres;Sylvie Behillil;Ahidjo Ayouba;Martin Foudi Maidadi;Dowbiss Meta Djomsi;Celestin Godwe;Christelle Butel;Aistis Šimaitis;Miglė Gabrielaitė;Monika Katėnaitė;Rimvydas Norvilas;Ligita Raugaitė;Giscard Wilfried Koyaweda;Jephté Kaleb Kandou;Rimvydas Jonikas;Inga Nasvytienė;Živilė Žemeckienė;Dovydas Gečys;Kamilė Tamušauskaitė;Milda Norkienė;Emilija Vasiliūnaitė;Danguolė Žiogienė;Albertas Timinskas;Marius Šukys;Mantas Šarauskas;Gediminas Alzbutas;Adrienne Amuri Aziza;Eddy Kinganda Lusamaki;Jean-Claude Makangara Cigolo;Francisca Muyembe Mawete;Emmanuel Lokilo Lofiko;Placide Mbala Kingebeni;Jean-Jacques Muyembe Tamfum;Marie Roseline Darnycka Belizaire;René Ghislain Essomba;Marie Claire Okomo Assou | pubmed | |||||
40 | 34595567 | Using the lung ultrasound score to monitor disease progression for COVID-19-associated ARDS. | 30 September 2021 00:00 | Letter | FR | en | Department of Anaesthesiology and Intensive Care, CHU Dijon, BP77908, 21709, Dijon Cedex, France.;Université Bourgogne Franche‑Comté, LNC UMR1231, 21000, Dijon, France.;Department of Anaesthesiology and Intensive Care, CHU Dijon, BP77908, 21709, Dijon Cedex, France. belaid_bouhemad@hotmail.com.;Université Bourgogne Franche‑Comté, LNC UMR1231, 21000, Dijon, France. belaid_bouhemad@hotmail.com. | Maxime Nguyen;Guillaume Gaujard;Pierre-Grégoire Guinot;Belaid Bouhemad | pubmed | |||||||||
41 | 34601112 | Answer to Mungmunpuntipantip et al « SARS CoV-2 vaccine AND rituximab» Joint Bone Spine 2021;88:105281. | 30 September 2021 00:00 | Letter | FR | en | Department of Rheumatology, CHRU de Besançon, 3 boulevard Fleming, 25000 Besançon, FRANCE, EA 4267 "PEPITE", UFR Santé, Franche-Comté University, 19 rue Ambroise Paré bâtiment S, 25030 Besançon cedex, France. Electronic address: fverhoeven@chu-besancon.fr.;Virology laboratory, CHRU de Besançon, 3 boulevard Fleming, 25000 Besançon, FRANCE.;Department of Rheumatology, CHRU de Besançon, 3 boulevard Fleming, 25000 Besançon, FRANCE.;Department of Rheumatology, CHRU de Besançon, 3 boulevard Fleming, 25000 Besançon, FRANCE, EA 4267 "PEPITE", UFR Santé, Franche-Comté University, 19 rue Ambroise Paré bâtiment S, 25030 Besançon cedex, France.;Department of Rheumatology, CHRU de Besançon, 3 boulevard Fleming, 25000 Besançon, FRANCE, EA 4266 « EPILAB », UFR Santé, Franche-Comté University, 19 rue Ambroise Paré bâtiment S, 25030 Besançon cedex, FRANCE. | Frank Verhoeven;Quentin Lepiller;Sophie Hecquet;Clément Prati;Daniel Wendling | COVID;Rituximab;vaccine | pubmed | ||||||||
42 | 34601145 | 10.1016/j.ijid.2021.09.076 | SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France. | 30 September 2021 00:00 | Journal Article | FR | en | 1201-9712 | Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.;Laboratoire de Virologie, CHU de Montpellier - 80 av Augustin Fliche, Montpellier 34295, France.;Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), AP-HP, Hôpital Pitié-Salpêtriére, Service de Virologie - 47-83 bd de l'Hôpital, Paris 75013, France.;MIVEGEC, Univ. Montpellier, CNRS, IRD - 911 av Agropolis, Montpellier Cedex 5 34394, France.;MIVEGEC, Univ. Montpellier, CNRS, IRD - 911 av Agropolis, Montpellier Cedex 5 34394, France. Electronic address: mircea.sofonea@umontpellier.fr. | International Journal of Infectious Diseases | SARS-CoV-2 variants raise concern regarding the mortality caused by COVID-19 epidemics. We analyse 88,375 cycle amplification (Ct) values from variant-specific RT-PCR tests performed between January 26 and March 13, 2021. We estimate that on March 12, nearly 85% of the infections were caused by the Alpha variant and that its transmission advantage over wild type strains was between 38 and 44%. We also find that tests positive for Alpha and Beta/Gamma variants exhibit significantly lower cycle threshold (Ct) values. | Benedicte Roquebert;Stéphanie Haim-Boukobza;Sabine Trombert-Paolantoni;Emmanuel Lecorche;Laura Verdurme;Vincent Foulongne;Sonia Burrel;Samuel Alizon;Mircea T Sofonea | pubmed | |||||
43 | 34600975 | Focus on the decisions to forego life-sustaining therapies during ICU stay of patients with cirrhosis and COVID-19: a case control study from the prospective COVID-ICU database. | 30 September 2021 00:00 | Letter | FR | en | Department of Anesthesiology and Critical Care, Beaujon Hospital, DMU Parabol, AP-HP Nord, Clichy, France. Electronic address: mikhael.giabicani@aphp.fr.;Department of Anesthesiology and Critical Care, Beaujon Hospital, DMU Parabol, AP-HP Nord, Clichy, France.;Service d'Hépatologie, Centre de Références des Maladies Vasculaires du Foie, Hôpital Beaujon, DMU DIGEST, AP-HP Nord, Clichy, France.;Université de Paris, AP-HP, Hôpital Beaujon, Service d'Hépatologie, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Centre de recherche sur l'inflammation, Inserm, UMR 1149, Paris, France.;Department of Anesthesiology and Critical Care, Beaujon Hospital, DMU Parabol, AP-HP Nord, Clichy, France, Inserm UMR_S1149, Inserm et Université de Paris, Paris, France. | Mikhael Giabicani;Alice Le Menestrel;Olivier Roux;Pierre-Emmanuel Rautou;Emmanuel Weiss | pubmed | |||||||||
44 | 34611466 | 10.1007/s12571-021-01215-2 | Do agri-food market incentives improve food security and nutrition indicators? a microsimulation evaluation for Kenya. | 30 September 2021 00:00 | Journal Article | ES;AR;FR | en | 1876-4517,1876-4525 | Facultad de Ciencias Económicas, Departamento de Economía. CONICET-Universidad de Buenos Aires, Instituto Interdisciplinario de Economía Política de Buenos Aires (IIEP-Baires), Universidad de Buenos Aires, Avda. Córdoba 2122 C1120AAQ, Buenos Aires, Argentina.;Centre d'Etudes Prospectives et d'Information Internationale (CEPII), 20 avenue de Ségur, 10726 75334 Paris cedex 07, TSA France.;European Commission, Joint Research Centre (JRC), Edificio Expo, Calle Inca Garcilaso, 41092 Seville, Spain.;Instituto de Salud Carlos III, Centro Nacional de Medicina Tropical, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain.;Departamento de Análisis Económico, Universidad de Zaragoza, Gran Vía 2, 50001 Zaragoza, Spain.;Departamento de Economía Aplicada III, Universidad de Sevilla, Avda. Ramón y Cajal, 1, 41018 Seville, Spain. | Food Security | The sustainable development goal #2 aims at ending hunger and malnutrition by 2030. Given the numbers of food insecure and malnourished people on the rise, the heterogeneity of nutritional statuses and needs, and the even worse context of COVID-19 pandemic, this has become an urgent challenge for food-related policies. This paper provides a comprehensive microsimulation approach to evaluate economic policies on food access, sufficiency (energy) and adequacy (protein, fat, carbohydrate) at household level. The improvement in market access conditions in Kenya is simulated as an application case of this method, using original insights from households' surveys and biochemical and nutritional information by food item. Simulation's results suggest that improving market access increases food purchasing power overall the country, with a pro-poor impact in rural areas. The daily energy consumption per capita and macronutrients intakes per capita increase at the national level, being the househo | María Priscila Ramos;Estefanía Custodio;Sofía Jiménez;Alfredo J Mainar-Causapé;Pierre Boulanger;Emanuele Ferrari | Africa;Food security;Household survey;Kenya;Market access;Microsimulations;Nutrition | pubmed | ||||
45 | 34600136 | 10.1016/j.ijid.2021.09.063 | Household transmission of SARS-CoV-2: a prospective observational study in Bosnia and Herzegovina, August - December 2020. | 29 September 2021 00:00 | Journal Article | FR;DK;BA | en | 1201-9712 | Institute for Public Health of the Federation of Bosnia and Herzegovina, Maršala Tita 9, Sarajevo, Bosna and Herzegovina, Sarajevo School of Science and Technology, Hrasnička cesta 3a, Sarajevo, Bosnia and Herzegovina. Electronic address: s.musa@zzjzfbih.ba.;Epiconcept, rue Titon 25 Paris, France. Electronic address: e.kissling@epiconcept.fr.;Epiconcept, rue Titon 25 Paris, France. Electronic address: m.valenciano@epiconcept.fr.;World Health Organization Office in Bosnia and Herzegovina, Zmaja od Bosne BB, Sarajevo, Bosnia and Herzegovina. Electronic address: faris.dizdar@hotmail.com.;Institute for Public Health of the Federation of Bosnia and Herzegovina, Maršala Tita 9, Sarajevo, Bosna and Herzegovina. Electronic address: m.blazevic@zzjzfbih.ba.;Sarajevo School of Science and Technology, Hrasnička cesta 3a, Sarajevo, Bosnia and Herzegovina, Public Health Institute of Canton Sarajevo, Dr. Mustafe Pintola 1, Sarajevo, Bosnia and Herzegovina. Electronic address: anesjoguncic@outlook.com | International Journal of Infectious Diseases | We estimated the secondary attack rate (SAR) of SARS-CoV-2 and identified risk factors for infection among members of households with a COVID-19 index case to inform preventive measures. | Sanjin Musa;Esther Kissling;Marta Valenciano;Faris Dizdar;Mia Blažević;Anes Jogunčić;Mirza Palo;Lore Merdrignac;Richard Pebody;Pernille Jorgensen | Bosnia and Herzegovina;COVID-19;Household transmission;SARS-CoV-2 | pubmed | ||||
46 | 34586649 | 10.1111/jpi.12772 | Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2. | 29 September 2021 00:00 | Journal Article | FR | en | 0742-3098,1600-079X | Université de Paris, Institut Cochin, INSERM, CNRS, PARIS, F-75014, France.;UMR Virologie, INRAE, ANSES, École Nationale Vétérinaire d'Alfort, Maisons-Alfort, F-94700, France.;Université Paris-Saclay, School of Medicine Le Kremlin-Bicêtre, Hôpital Marie Lannelongue, INSERM UMRS 999, Le Plessis-Robinson, France. | Journal of Pineal Research | As the COVID-19 pandemic grows, several therapeutic candidates are being tested or undergoing clinical trials. Although prophylactic vaccination against SARS-CoV-2 infection has been shown to be effective, no definitive treatment exists to date in the event of infection. The rapid spread of infection by SARS-CoV-2 and its variants fully warrants the continued evaluation of drug treatments for COVID-19, especially in the context of repurposing of already available and safe drugs. Here we explored the therapeutic potential of melatonin and melatonergic compounds in attenuating COVID-19 pathogenesis in mice expressing human ACE2 receptor (K18-hACE2), strongly susceptible to SARS-CoV-2 infection. Daily administration of melatonin, agomelatine or ramelteon delays the occurrence of severe clinical outcome with improvement of survival, especially with high melatonin dose. Although no changes in most lung inflammatory cytokines are observed, treatment with melatonergic compounds limits the exa | Erika Cecon;Charlotte Izabelle;Sophie Le Poder;Fernando Real;Aiwei Zhu;Ly Tu;Maria Rosa Ghigna;Bernard Klonjkowski;Morgane Bomsel;Ralf Jockers;Julie Dam | Agomelatine;COVID-19;Melatonin;Ramelteon;SARS-CoV-2;drug repurposing;interferons | pubmed | ||||
47 | 34600020 | Decreasing humoral response among healthcare workers up to 4 months after two doses of BNT162b2 vaccine. | 29 September 2021 00:00 | Letter | FR | en | Université de Paris, IAME, UMR1137, INSERM, F-75018 Paris, France, AP-HP, Hôpital Bichat-Claude Bernard, Virologie, Paris, France. Electronic address: valentinemarie.ferre@aphp.fr.;Université de Paris, IAME, UMR1137, INSERM, F-75018 Paris, France.;Université de Paris, IAME, UMR1137, INSERM, F-75018 Paris, France, AP-HP, Hôpital Bichat-Claude Bernard, Virologie, Paris, France.;AP-HP, Hôpital Bichat-Claude Bernard, Virologie, Paris, France.;Université de Paris, IAME, UMR1137, INSERM, F-75018 Paris, France, AP-HP, Hôpital Bichat-Claude Bernard, Maladies Infectieuses et Tropicales, Paris, France.;Université de Paris, IAME, UMR1137, INSERM, F-75018 Paris, France, AP-HP, Hôpital Bichat-Claude Bernard, Réanimation Médicale et Infectieuse, Paris, France. | Valentine Marie Ferré;Samuel Lebourgeois;Reyene Menidjel;Gilles Collin;Houssem Redha Chenane;Manuella Onambele Guindi;Yazdan Yazdanpanah;Jean-François Timsit;Charlotte Charpentier;Diane Descamps;Nadhira Fidouh;Benoit Visseaux | BNT162b2 vaccine;COVID-19;SARS-CoV-2;antibodies;humoral response;mRNA vaccine | pubmed | ||||||||
48 | 34506995 | 10.1016/j.gofs.2021.09.006 | [Impact of SARS-CoV-2 on fertility, gametes' quality and Assisted Reproduction Technology]. | 29 September 2021 00:00 | English Abstract;Journal Article | FR | fr | 2468-7189 | Département de biologie de la reproduction, biologie de la reproduction/DPI et CECOS, CHU d'Arnaud de Villeneuve Montpellier, université de Montpellier, Montpellier, France.;Inserm 1203, développement embryonnaire précoce humain et pluripotence, Embryopluripotency, université de Montpellier, Montpellier, France, Service de pédiatrie, unité d'endocrinologie-gynécologie pédiatrique, CHU d'Arnaud de Villeneuve Montpellier, université de Montpellier, Montpellier, France.;Inserm 1203, développement embryonnaire précoce humain et pluripotence, Embryopluripotency, université de Montpellier, Montpellier, France, Département de biologie de la reproduction, biologie de la reproduction/DPI et CECOS, CHU d'Arnaud de Villeneuve Montpellier, université de Montpellier, Montpellier, France.;Inserm 1203, développement embryonnaire précoce humain et pluripotence, Embryopluripotency, université de Montpellier, Montpellier, France, Département de biologie de la reproduction, biologie de la reproduction/DP | Gynécologie Obstétrique Fertilité & Sénologie | The current pandemic context raises questions about COVID-19 consequences on Assisted Reproduction Technology (ART). Indeed, according to the first Biomedicine Agency recommendations, ART centers suspended their activities in March 2020 during the first wave of Covid-19. However, SARS-CoV-2 direct and indirect effects on gametes, fertility, pregnancy and neonatal health are still debated. The aim of this review is to assess the available data on this subject, to inform patients in care and adapt daily practice. Most recent studies are based on the effects of the infectious syndrome, on hormonal factors as well as on the expression of viral entry proteins (ACE2 and TMPRSS2) in cells involved in gametogenesis, to assess the impact of COVID-19. So far, no effect on female gametes was highlighted. More studies are needed to confirm this hypothesis. Mother to children transmission couldn't be proven, yet neonatal infection remains possible. However, men are more susceptible to be infected b | Julie Nobre Meirinhos;Margot Vattaire;Fatima Barry;Louise Denjean;Molka Bouricha;Anna Gala;Alice Ferrières-Hoa;Vanessa Loup;Laura Gaspari;Sophie Brouillet;Samir Hamamah | AMP;ART;COVID-19;Fertility;Fertilité;Gametes;Gamètes | pubmed | ||||
49 | 34600148 | SARS-CoV-2, polymyalgia rheumatica and giant cell arteritis: COVID19 vaccine shot as a trigger? Comment on :Can SARS-CoV-2 trigger relapse of polymyalgia rheumatica?" by Manzo et al. Joint Bone Spine 2021;88:105150. | 29 September 2021 00:00 | Letter | FR | en | Univ Rennes, Department of Rheumatology, Rennes University Hospital, France. Electronic address: simon.cadiou@chu-rennes.fr.;Univ Rennes, Department of Rheumatology, Rennes University Hospital, France.;Univ Rennes, Department of Internal Medicine and Clinical Immunology, Rennes University Hospital, France.;Univ Rennes, Department of Rheumatology, Rennes University Hospital, France, Univ Rennes, INSERM UMR 1241, INRA, 35000, Rennes, France. Institut NUMECAN (Nutrition Metabolisms and Cancer), France.;Univ Rennes, Department of Internal Medicine and Clinical Immunology, Rennes University Hospital, France, Univ. Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France. | Simon Cadiou;Aleth Perdriger;Samuel Ardois;Jean-David Albert;Olivia Berthoud;Alain Lescoat;Pascal Guggenbuhl;François Robin | COVID19;SARS-CoV-2;giant cell arteritis;polymyalgia rheumatic;vaccine | pubmed | ||||||||
50 | 34583990 | 10.1073/pnas.2104684118 | Inequality in mortality between Black and White Americans by age, place, and cause and in comparison to Europe, 1990 to 2018. | 29 September 2021 00:00 | Journal Article;Research Support, Non-U.S. Gov't | NO;ES;IT;US;FI;DE;NL;FR;SE;GB;PT | en | 0027-8424,1091-6490 | School of Education and Social Policy, Northwestern University, Evanston, IL 60208.;Department of Economics, Princeton University, Princeton, NJ 08540, jcurrie@princeton.edu.;Erasmus School of Health Policy & Management, Erasmus University Rotterdam, 3000DR Rotterdam, The Netherlands.;Institute for Fiscal Studies, London WC1E 7AE, United Kingdom.;Department of Economics, University of Manchester, Manchester M13 9PL, United Kingdom.;Department of Economics, University of Verona, 37129 Verona, Italy.;Department of Economics, Norwegian School of Economics, Bergen, 5045, Norway.;Centre of Studies in Geography and Spatial Planning, University of Coimbra, 3004-531, Coimbra, Portugal.;Department of Economics and Business, Universitat Pompeu Fabra, 08005 Barcelona, Spain.;Department of Economics, Management, and Quantitative Methods, University of Milan, 20122 Milano, Italy.;Department of Economics, Aalto University School of Business, 02150 Espoo, Finland.;VATT Institute for Economic Research | Proceedings of the National Academy of Sciences | Although there is a large gap between Black and White American life expectancies, the gap fell 48.9% between 1990 and 2018, mainly due to mortality declines among Black Americans. We examine age-specific mortality trends and racial gaps in life expectancy in high- and low-income US areas and with reference to six European countries. Inequalities in life expectancy are starker in the United States than in Europe. In 1990, White Americans and Europeans in high-income areas had similar overall life expectancy, while life expectancy for White Americans in low-income areas was lower. However, since then, even high-income White Americans have lost ground relative to Europeans. Meanwhile, the gap in life expectancy between Black Americans and Europeans decreased by 8.3%. Black American life expectancy increased more than White American life expectancy in all US areas, but improvements in lower-income areas had the greatest impact on the racial life expectancy gap. The causes that contributed | Hannes Schwandt;Janet Currie;Marlies Bär;James Banks;Paola Bertoli;Aline Bütikofer;Sarah Cattan;Beatrice Zong-Ying Chao;Claudia Costa;Libertad González;Veronica Grembi;Kristiina Huttunen;René Karadakic;Lucy Kraftman;Sonya Krutikova;Stefano Lombardi;Peter Redler;Carlos Riumallo-Herl;Ana Rodríguez-González;Kjell G Salvanes;Paula Santana;Josselin Thuilliez;Eddy van Doorslaer;Tom Van Ourti;Joachim K Winter;Bram Wouterse;Amelie Wuppermann | age-specific mortality;area-level socioeconomic status;international comparison;life expectancy;racial divide | pubmed | ||||
51 | 34586754 | 10.1002/oby.23314 | History of bariatric surgery and COVID 19 outcomes in patients with type 2 diabetes: results from the CORONADO study. | 29 September 2021 00:00 | Journal Article | FR | en | 1930-7381,1930-739X | Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.;Chirurgie Cancérologique Digestive et Endocrinienne (CCDE), Institut des Maladies de l'Appareil Digestif (IMAD), Centre Hospitalo-universitaire de Nantes (CHU) Hôtel-Dieu, Nantes, France.;CHU de Nantes, INSERM CIC 1413, Pôle Hospitalo-Universitaire 11 : Santé Publique, Clinique des données, Nantes, France.;Département d'Endocrinologie, Diabétologie et Nutrition, CHU Toulouse, Institut des Maladies Métaboliques et Cardiovasculaires, UMR1297, INSERM/UPS, Université de Toulouse, Toulouse, France.;Laboratoire de Biochimie, CHU de Nantes, Hôpital G et R Laënnec, Bd Jacques Monod, Nantes, France.;Hôpital d'instruction des Armées Bégin, Saint Mandé, France.;Département d'Endocrinologie, Diabétologie et Nutrition, CHU de Besançon, Besançon, France.;Sorbonne Université, Assistance Publique Hôpitaux de Paris, Département de Diabétologie, CHU La Pitié Salpêtrière-Charles Foix, Inserm, UMR_S 1138, Centre | Obesity | The objective of this study is to assess the impact of a history of metabolic and bariatric surgery (MBS) on the clinical outcomes in patients with type 2 diabetes (T2D) and severe obesity hospitalized for COVID-19. | Claire Blanchard;Tanguy Perennec;Sarra Smati;Blandine Tramunt;Béatrice Guyomarch;Edith Bigot-Corbel;Lyse Bordier;Sophie Borot;Olivier Bourron;Cyrielle Caussy;Christine Coffin-Boutreux;Anne Dutour;Natacha Germain;Céline Gonfroy-Leymarie;Laurent Meyer;Gaëtan Prevost;Ronan Roussel;Dominique Seret-Bégué;Charles Thivolet;Bruno Vergès;Matthieu Pichelin;Pierre Gourdy;Samy Hadjadj;Matthieu Wargny;François Pattou;Bertrand Cariou | COVID-19;Metabolic and Bariatric Surgery;Type 2 Diabetes | pubmed | ||||
52 | 34600019 | 10.1016/j.jinf.2021.09.016 | Decreasing proportion of extended-spectrum beta-lactamase among E. coli infections during the COVID-19 pandemic in France. | 29 September 2021 00:00 | Journal Article | FR;GB | en | 0163-4453 | Centre d'appui à la prévention des infections associées aux soins des Pays de la Loire. Nantes, France.;Santé Publique France, Département des Maladies Infectieuses, Saint Maurice, France.;Centre d'appui à la prévention des infections associées aux soins des Pays de la Loire. Nantes, France, NIHR Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance at Imperial College London, Hammersmith Campus, Du Cane Road, London, UK. Electronic address: gabriel.birgand@chu-nantes.fr. | Journal of Infection | We investigated the impact of the COVID-19 and national pandemic response on the epidemiology of Extended Spectrum Beta-Lactamase producing E. coli (ESBL-E.coli) in France. | Olivier Lemenand;Thomas Coeffic;Sonia Thibaut;Melanie Colomb-Cotinat;Jocelyne Caillon;Gabriel Birgand | Antimicrobial resistance;COVID-19;ESBL-E.coli;Nursing homes;Outpatient | pubmed | ||||
53 | 34604721 | 10.1016/j.isci.2021.103185 | SARS-CoV-2 integral membrane proteins shape the serological responses of COVID-19 patients. | 29 September 2021 00:00 | Journal Article | FR;SE | en | 2589-0042 | Inserm U1242 Oncogenesis Stress Signaling, Rennes, 35000, France.;Centre Eugène Marquis, Rennes, 35000, France.;Department of Virology, CHU Pontchaillou, Rennes, 35000, France.;Department of Chemistry & Molecular Biology, University of Gothenburg, Göteborg, 41390, Sweden. | iScience | SARS-CoV-2 pandemic has elicited a unique mobilization of the scientific community to develop efficient tools to understand and combat infection. Like other coronavirae, SARS-CoV-2 hijacks host cell secretory machinery to produce viral proteins that compose the nascent virions; including Spike (S), Envelope (E) and Membrane (M) proteins, the most exposed transmembrane proteins to the host immune system. As antibody response is part of the anti-viral immune arsenal, we investigate the immunogenic potential of S, E and M using a human cell-based system to mimic membrane insertion and N-glycosylation. Both S and M elicit specific Ig production in SARS-CoV-2 patients. Patients with moderate and severe diseases exhibit elevated Ig responses. Finally, reduced Ig binding was observed with Spike G614 compared to D614 variant. Altogether, our assay points towards an unexpected immune response against M and represents a powerful tool to test humoral responses against actively evolving SARS-CoV-2 | Sophie Martin;Christopher Heslan;Gwénaële Jégou;Leif A Eriksson;Matthieu Le Gallo;Vincent Thibault;Eric Chevet;Florence Godey;Tony Avril | M;SARS-CoV-2;Spike;envelope proteins;serology | pubmed | ||||
54 | 34586866 | 10.1128/jvi.01267-21 | Genetic and Antigenic Characterization of an Influenza A(H3N2) Outbreak in Cambodia and the Greater Mekong Subregion during the COVID-19 Pandemic, 2020. | 29 September 2021 00:00 | Journal Article | KH;US;CN;FR;AU;HK | en | 0022-538X,1098-5514 | National Influenza Center of Cambodia, Virology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.;School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.;HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.;World Health Organization Collaborating Center, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.;World Health Organization Country Office, Phnom Penh, Cambodia.;U.S. Centers for Disease Control and Prevention, Phnom Penh, Cambodia.;National Institute of Public Health, Ministry of Health, Phnom Penh, Cambodia.;Centers for Disease Control and Prevention, Ministry of Health, Phnom Penh, Cambodia. | Journal of Virology | Introduction of non-pharmaceutical interventions to control COVID-19 in early 2020 coincided with a global decrease in active influenza circulation. However, between July and November 2020, an influenza A(H3N2) epidemic occurred in Cambodia and in other neighboring countries in the Greater Mekong Subregion in Southeast Asia. We characterized the genetic and antigenic evolution of A(H3N2) in Cambodia and found that the 2020 epidemic comprised genetically and antigenically similar viruses of Clade3C2a1b/131K/94N, but they were distinct from the WHO recommended influenza A(H3N2) vaccine virus components for 2020-2021 Northern Hemisphere season. Phylogenetic analysis revealed multiple virus migration events between Cambodia and bordering countries, with Laos PDR and Vietnam also reporting similar A(H3N2) epidemics immediately following the Cambodia outbreak: however, there was limited circulation of these viruses elsewhere globally. In February 2021, a virus from the Cambodian outbreak was | Jurre Y Siegers;Vijaykrishna Dhanasekaran;Ruopeng Xie;Yi-Mo Deng;Sarika Patel;Vanra Ieng;Jean Moselen;Heidi Peck;Ammar Aziz;Borann Sarr;Savuth Chin;Seng Heng;Asheena Khalakdina;Michael Kinzer;Darapheak Chau;Philomena Raftery;Veasna Duong;Ly Sovann;Ian G Barr;Erik A Karlsson | pubmed | |||||
55 | 34600007 | 10.1016/j.chemosphere.2021.132364 | Reuse of medical face masks in domestic and community settings without sacrificing safety: Ecological and economical lessons from the Covid-19 pandemic. | 29 September 2021 00:00 | Journal Article | FR | en | 0045-6535 | Univ. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG, 38000, Grenoble, France.;IMT Atlantique, GEPEA, CNRS UMR 6144, CS 20722, 44307, Nantes, France.;Mines Saint-Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, F-42023, Saint-Etienne, France.;Université de Lorraine, CNRS UMR 7274 LRGP, Nancy, 54001, France.;INRS, Département Ingénierie des Procédés, France.;Clinical Investigation Center-Technological Innovation 1406 (CIC-IT), Department of Public Health, Grenoble Alpes University Hospital, Grenoble, France.;CIC Inserm 1433 Innovation Technologiques, CHRU de Nancy, Université de Lorraine, 54000, Nancy, France.;Centre Hospitalier Universitaire Grenoble Alpes, 38700, La Tronche, France.;ARC-Nucleart, CEA Grenoble, 17, rue des Martyrs, Cedex 9, 38054, Grenoble, France.;Ionisos SAS, 13 Chemin du Pontet, Civrieux-d'Azergues, 69380, France.;CIRI (Centre International de Recherche en Infectiologie), Equipe GIMAP (team 15), INSERM U1111, CNRS, ENS, UCBL1, Université Je | Chemosphere | The need for personal protective equipment increased exponentially in response to the Covid-19 pandemic. To cope with the mask shortage during springtime 2020, a French consortium was created to find ways to reuse medical and respiratory masks in healthcare departments. The consortium addressed the complex context of the balance between cleaning medical masks in a way that maintains their safety and functionality for reuse, with the environmental advantage to manage medical disposable waste despite the current mask designation as single-use by the regulatory frameworks. We report a Workflow that provides a quantitative basis to determine the safety and efficacy of a medical mask that is decontaminated for reuse. The type IIR polypropylene medical masks can be washed up to 10 times, washed 5 times and autoclaved 5 times, or washed then sterilized with radiations or ethylene oxide, without any degradation of their filtration or breathability properties. There is loss of the anti-projecti | Jean-Pierre Alcaraz;Laurence Le Coq;Jérémie Pourchez;Dominique Thomas;Sandrine Chazelet;Isabelle Boudry;Maud Barbado;Sophie Silvent;Claire Dessale;Fabienne Antoine;Catherine Guimier-Pingault;Laurent Cortella;Sophie Rouif;Nathalie Bardin-Monnier;Augustin Charvet;Olivier Dufaud;Lara Leclerc;Yoann Montigaud;Coralie Laurent;Paul Verhoeven;Aurélie Joubert;Ala Bouhanguel;Yves Andres;Joël Gaffé;Donald K Martin;Christophe Huet;Sandrine Boisset;Max Maurin;Pascal Rumeau;Frédéric Charlot;Emmanuel Richaud;Alexandre Moreau-Gaudry;Vincent Bonneterre;Philippe Cinquin;Caroline Landelle | Covid-19;Filtration;Mask;Polypropylene;Reuse;Waste management | pubmed | ||||
56 | 34587889 | 10.2174/1871526521666210929121705 | COVID-19 in pediatrics: The current knowledge and practice. | 29 September 2021 00:00 | Journal Article | IR;US;FR | en | 1871-5265 | Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal. Iran.;HBOT Research Center, Golestan Hospital, Islamic Republic of Iran, Navy and AJA Medical university, Tehran. Iran.;Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran. Iran.;School of medicine, Tehran University of Medical Sciences, Tehran. Iran.;Department of Radiology,School of Medicine,University of California, San Diego (UCSD), California. United States.;School of medicine, Islamic Azad University, Tehran. Iran.;MD, Ophthalmology Resident at Farabi Hospital, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran. Iran.;Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran. Iran.;Department of Physiotherapy, Tehran University of Medical Sciences, Tehran. Iran.;School of medicine, Iran University of Medical sciences. Iran.;Department of Hea | Infectious Disorders - Drug Targets | SARS-CoV-2 is the novel coronavirus that causes severe acute respiratory syndrome and could afflict individuals from all walks of life. Children are usually asymptomatic or represent non-specific mild to moderate symptoms; therefore, they often remain undiagnosed and could be potential reservoirs and silent carriers of the virus. Despite the global attention to COVID-19 and its importance in public health, some clinical and paraclinical aspects of this disease in children are still unclear. Thus, we conducted a comprehensive systematic review of available literature to reflect on the current knowledge and practice of the disease among children. | Esmaeil Mehraeen;Shahram Oliaei;SeyedAhmad SeyedAlinaghi;Amirali Karimi;Pegah Mirzapour;Amir Masoud Afsahi;Alireza Barzegary;Farzin Vahedi;Mahdi Soleymanzadeh;Farzane Behnezhad;Mohammad Javaherian;Ghazal Zargari;Seyed Peyman Mirghaderi;Tayebeh Noori;Jean-Marc Sabatier | COVID-19;Children;Coronavirus;Morbidity;Mortality;Pediatrics;Prognosis;SARS-CoV-2 | pubmed | ||||
57 | 34586376 | 10.1093/cid/ciab531 | Corrigendum to: Correlation Between 3790 Quantitative Polymerase Chain Reaction-Positives Samples and Positive Cell Cultures, Including 1941 Severe Acute Respiratory Syndrome Coronavirus 2 Isolates. | 29 September 2021 00:00 | Published Erratum | FR;VN | en | 1058-4838,1537-6591 | Institut Hospitalo-Universitaire (IHU)-Méditerranée Infection, Marseille, France.;Aix Marseille Univ, Institut pour le Recherche et le Developpement (IRD), Assistance Publique Hopitaux de Marseille (AP-HM), Microbes Evolution and Phylogeny (MEPHI), Marseille, France.;Aix Marseille Univ, Institut pour le Recherche et le Developpement (IRD), Assistance Publique Hopitaux de Marseille (AP-HM), SSA, Vecteurs Infection Tropicales et Mediterraneennes (VITROME), Marseille, France.;Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam. | Clinical Infectious Diseases | Rita Jaafar;Sarah Aherfi;Nathalie Wurtz;Clio Grimaldier;Van Thuan Hoang;Philippe Colson;Didier Raoult;Bernard La Scola | pubmed | ||||||
58 | 34596097 | 10.1097/phm.0000000000001898 | Benefits of 1-year home training with FES cycling in paraplegia during Covid-19 crisis: case report. | 29 September 2021 00:00 | Journal Article | FR | en | 0894-9115 | Rehabilitation Center Bouffard-Vercelli, PM&R, Perpignan, France INRIA, University of Montpellier, CNRS, Montpellier, France Rehabilitation Center La Châtaigneraie, PM&R, Menucourt, France Hospital Center, Department of Sports Medicine, Saint Germain-en-Laye, France University Hospital Center Raymond Poincaré, Department of Medical Imagery, Garches, France. | American Journal of Physical Medicine & Rehabilitation | The purpose of this observational study was to report the experience of a one-year home training with Functional Electrical Stimulation (FES) cycling of a person with T4 AIS A paraplegia for 9 years, homebound due to the Covid 19 health crisis. The 40-year-old participant had a 3-phase training: V1: isometric stimulation, V2: FES-cycling for 3 sessions/week, and V3: FES-cycling for 2 to 4 sessions/week. Data on general and physical tolerance, health impact and performance were collected. Borg score relating to fatigue was 10.1 before training and 11.8 after training. The average score for satisfaction at the end of sessions was 8.7. Lean leg mass increased more than 29%, although total bone mineral density dropped by 1.6%. The ventilatory thresholds increased from 19.5 to 29% and VEmax increased by 9.5%. Rosenberg's self-esteem score returned to its highest level by the end of training. For the only track event on a competition bike, the pilot covered a distance of 1607.8 m in 17'49". | Charles Fattal;Martin Schmoll;Ronan Le Guillou;Berengère Raoult;Alain Frey;Robert Carlier;Christine Azevedo-Coste | pubmed | |||||
59 | 34583560 | 10.1098/rsif.2021.0319 | Which features of an outpatient treatment for COVID-19 would be most important for pandemic control? A modelling study. | 29 September 2021 00:00 | Journal Article;Research Support, Non-U.S. Gov't | FR | en | 1742-5662 | AGIR UR4294, Jules Verne University of Picardie, Amiens, France.;Infectious Disease Department, Amiens-Picardie University Medical Center, Amiens, France.;LAMFA, CNRS UMR7352, Picardie Jules Verne University, Amiens, France.;GRECO, Jules Verne University of Picardie, Amiens, France.;Neurosurgery Department, Amiens-Picardie University Medical Center, Amiens, France. | Journal of The Royal Society Interface | COVID-19;Communicable Disease Control;Humans;Outpatients;Pandemics__prevention & control;SARS-CoV-2 | The global pandemic of coronavirus disease 2019 (COVID-19) has challenged healthcare systems worldwide. Lockdown, social distancing, and screening are thought to be the best means of stopping the virus from spreading and thus of preventing hospital capacity from being overloaded. However, it has also been suggested that effective outpatient treatment can control pandemics. We adapted a mathematical model of the beneficial effect of lockdown on viral transmission and used it to determine which characteristics of outpatient treatment would stop an epidemic. The data on confirmed cases, recovered cases, and deaths were collected from Santé Publique France. After defining components of the epidemic flow, we used a Morris global sensitivity analysis with a 10-level grid and 1000 trajectories to determine which of the treatment parameters had the largest effect. Treatment effectiveness was defined as a reduction in the patients' contagiousness. Early treatment initiation was associated with | Jean-Philippe Lanoix;Youcef Mammeri;Jean-Luc Schmit;Michel Lefranc | COVID-19;model;outpatient;pandemic;proactive treatment | pubmed | |||
60 | 34586843 | 10.1126/sciadv.abj2099 | Geographically targeted COVID-19 vaccination is more equitable and averts more deaths than age-based thresholds alone. | 29 September 2021 00:00 | Journal Article | FR;US | en | 2375-2548 | Department of Sociology, University of Minnesota, Twin Cities, Minneapolis, MN, USA.;Minnesota Population Center, University of Minnesota, Twin Cities, Minneapolis, MN, USA.;Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.;FXB Center for Health and Human Rights, Harvard University, Boston, MA, USA.;Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.;Department of Demography, University of California, Berkeley, CA, USA.;French Institute for Demographic Studies, Paris, France.;Institute for Global Health Sciences, University of California San Francisco, San Francisco, CA, USA.;Center for Health and Community, University of California San Francisco, San Francisco, CA, USA.;University of Minnesota School of Public Health, Minneapolis, MN, USA.;Department of Medicine, University of California San Francisco, San Francisco, CA, USA.;Division of Health Policy and Management, Un | Science Advances | [Figure: see text]. | Elizabeth Wrigley-Field;Mathew V Kiang;Alicia R Riley;Magali Barbieri;Yea-Hung Chen;Kate A Duchowny;Ellicott C Matthay;David Van Riper;Kirrthana Jegathesan;Kirsten Bibbins-Domingo;Jonathon P Leider | pubmed | |||||
61 | 34587623 | 10.1093/aje/kwab237 | Explaining ethnic differentials in COVID-19 mortality: cohort study. | 29 September 2021 00:00 | Journal Article | ES;FR;GB | en | 0002-9262,1476-6256 | Department of Epidemiology and Public Health, University College London, UK.;Paris Cardiovascular Research Center-INSERM U970, France.;MRC Lifecourse Epidemiology Unit, University of Southampton, UK, Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, UK.;Division of Surgery and Interventional Sciences, University College London, London.;Hospital del Mar Medical Research Institute, Barcelona, Spain, CIBER of Pathophysiology of Obesity and Nutrition, Madrid, Spain. | American Journal of Epidemiology | Ethnic inequalities in coronavirus disease 2019 (COVID-19) hospitalizations and mortality have been widely reported but there is scant understanding of how they are embodied. The UK Biobank prospective cohort study comprises around half a million people who were aged 40-69 years at study induction between 2006 and 2010 when information on ethnic background and potential explanatory factors was captured. Study members were prospectively linked to a national mortality registry. In an analytical sample of 448,664 individuals (248,820 women), 705 deaths were ascribed to COVID-19 between 5th March, 2020 and 24th January, 2021. In age- and sex-adjusted analyses, relative to White participants, Black study members experienced around five times the risk of COVID-19 mortality (odds ratio; 95% confidence interval: 4.81; 3.28, 7.05), while there was a doubling in the South Asian group (2.05; 1.30, 3.25). Controlling for baseline comorbidities, social factors (including socioeconomic circumstances | G David Batty;Bamba Gaye;Catharine R Gale;Mark Hamer;Camille Lassale | COVID-19;UK Biobank;cohort study;ethnicity | pubmed | ||||
62 | 34609954 | 10.3855/jidc.15057 | Going virtual for research training during the COVID-19 pandemic and beyond: e-SORT IT. | 29 September 2021 00:00 | Journal Article | AM;LU;CH;BE;FR;DK | en | 1972-2680 | Tuberculosis Research and Prevention Center, Yerevan, Armenia. haykdav@gmail.com.;World Health Organization Regional Office for Europe, Division of Country Health Policies and Systems (CPS), Copenhagen, Denmark.;International Union against Tuberculosis and Lung Disease, Paris, France.;Médecins Sans Frontières, Operational Centre Brussels, Operational Research Unit, LuxOR, Luxembourg.;UNICEF, UNDP, World Bank, WHO Special Programme for Research and Training in Tropical Disease (TDR), Geneva, Switzerland. | The Journal of Infection in Developing Countries | The Structured Operational Research and Training Initiative (SORT IT) model has contributed to building research capacity and has produced evidence for improving public health program performance in countries with limited research capacity. The model involves hands-on mentorship and consists of three modules/weeks. It is recognized to be an innovative research capacity building model. In a world changed by COVID-19, where bringing people together is not viable, an innovative, interactive, web-based, knowledge-transfer platform (e-SORT IT) for virtual implementation of SORT IT modules was created. The platform design imitated the residential course as closely as possible with the same lectures, plenary sessions, and breakout rooms. Despite the challenges, the platform performed well and even though participants and mentors were located in eight different time zones, the course was successful; 90% of participants achieved their milestones and 10 manuscripts were successfully completed. P | Hayk Davtyan;Karapet Davtyan;Anthony D Harries;Anthony Reid;Garry Aslanyan;Mohammed Khogali;Rony Zachariah | Capacity building;Digitalization;Online training;Operational research;SORT IT;e-SORT IT | pubmed | ||||
63 | 34599878 | 10.1016/s0140-6736(21)01960-7 | Extracorporeal membrane oxygenation for COVID-19: evolving outcomes from the international Extracorporeal Life Support Organization Registry. | 29 September 2021 00:00 | Journal Article | CA;US;CL;DE;NL;FR;SG | en | 0140-6736 | Division of Pediatric Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA. Electronic address: barbaror@med.umich.edu.;Cardiothoracic Intensive Care Unit, Department of Cardiac, Thoracic, and Vascular Surgery, National University Health System, Singapore.;Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.;Sorbonne Université, INSERM, UMRS1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France, Service de médecine intensive-réanimation, Institut de Cardiologie, APHP Sorbonne Hôpital Pitié-Salpêtrière, Paris, France.;Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York-Presbyterian Hospital, New York, NY, USA, Center for Acute Respiratory Failure, New York-Presbyterian Hospital, New York, NY, USA.;Department of Critical Care Medicine, The Hospital for Sick Children, Toronto, ON, Canada.;Clinica Las Condes, Santiago, Chile.;Interdepartmental D | The Lancet | Over the course of the COVID-19 pandemic, the care of patients with COVID-19 has changed and the use of extracorporeal membrane oxygenation (ECMO) has increased. We aimed to examine patient selection, treatments, outcomes, and ECMO centre characteristics over the course of the pandemic to date. | Ryan P Barbaro;Graeme MacLaren;Philip S Boonstra;Alain Combes;Cara Agerstrand;Gail Annich;Rodrigo Diaz;Eddy Fan;Katarzyna Hryniewicz;Roberto Lorusso;Matthew L Paden;Christine M Stead;Justyna Swol;Theodore J Iwashyna;Arthur S Slutsky;Daniel Brodie | pubmed | |||||
64 | 34599939 | 10.1016/j.jmb.2021.167277 | Discovery of genes that modulate flavivirus replication in an interferon-dependent manner. | 29 September 2021 00:00 | Journal Article | FR | en | 0022-2836 | Institut Pasteur, Virus Sensing and Signaling Unit, CNRS UMR3569, Paris, France, Université de Paris, Paris, France.;Institut Pasteur, Virus Sensing and Signaling Unit, CNRS UMR3569, Paris, France.;Institut Pasteur, Virus Sensing and Signaling Unit, CNRS UMR3569, Paris, France, Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.;Institut Pasteur, Molecular Genetics of RNA Viruses Unit, CNRS UMR3569, Université de Paris, Paris, France.;Institut Curie, PSL Research University, INSERM U932, Paris, France.;Institut Pasteur, Virus Sensing and Signaling Unit, CNRS UMR3569, Paris, France, Institut Pasteur, Insect-Virus Interactions Unit, Department of Virology, CNRS UMR2000, Paris, France.;Institut Curie, PSL Research University, Department of Translational Research-Biophenics High-Content Screening Laboratory, Cell and Tissue Imaging Facility (PICT-IBiSA), Paris, France.;Institut Pasteur, Viral Genomics and Vaccination Unit, CNRS | Journal of Molecular Biology | Establishment of the interferon (IFN)-mediated antiviral state provides a crucial initial line of defense against viral infection. Numerous genes that contribute to this antiviral state remain to be identified. Using a loss-of-function strategy, we screened an original library of 1156 siRNAs targeting 386 individual curated human genes in stimulated microglial cells infected with Zika virus (ZIKV), an emerging RNA virus that belongs to the flavivirus genus. The screen recovered twenty-one potential host proteins that modulate ZIKV replication in an IFN-dependent manner, including the previously known IFITM3 and LY6E. Further characterization contributed to delineate the spectrum of action of these genes towards other pathogenic RNA viruses, including Hepatitis C virus and SARS-CoV-2. Our data revealed that APOL3 acts as a proviral factor for ZIKV and several other related and unrelated RNA viruses. In addition, we showed that MTA2, a chromatin remodeling factor, possesses potent flaviv | Sarah Lesage;Maxime Chazal;Guillaume Beauclair;Damien Batalie;Silvia Cerboni;Elodie Couderc;Aurianne Lescure;Elaine Del Nery;Frédéric Tangy;Annette Martin;Nicolas Manel;Nolwenn Jouvenet | APOL3;MTA2;Zika virus;antiviral response;interferon-stimulated genes | pubmed | ||||
65 | 34588616 | 10.1038/s41416-021-01555-y | Multicenter evaluation of breast cancer patients' satisfaction and experience with oncology telemedicine visits during the COVID-19 pandemic. | 29 September 2021 00:00 | Journal Article | IT;FR | en | 0007-0920,1532-1827 | Medical Oncology Department, Gustave Roussy, Villejui, France.;Department of Biostatistics and Epidemiology, Gustave Roussy, University Paris-Saclay, Villejuif, France.;Oncostat U1018, Inserm, University Paris-Saclay, Labeled Ligue Contre le Cancer, Villejuif, France.;Medical Oncology Department, Centre Léon Bérard, Lyon, France.;Institut Normand du Sein, Centre Francois Baclesse, Caen, France.;Centre Oscar Lambret, Lille, France.;Breast and Gynecologic Surgery, Assistance Publique - Hopitaux De Paris, Paris, France.;Medical Oncology Department, CHU Limoges - Hopital Dupuytren, Limoges, France.;Medical Oncology Department, Clinique Chenieux, Limoges, France.;Breast Cancer Unit, American Hospital of Paris, Neuilly-Sur-Seine, France.;Breast Cancer Unit, AP university Hospital St Louis, Paris, France.;Medical Oncology Department, Institut Ste Catherine, Avignon, France.;Medical Oncology Department, ICO - Institut de Cancérologie de l'Ouest Nantes-Angers, Angers, France.;Medical Oncology D | British Journal of Cancer | During the COVID-19 pandemic, teleconsultation was implemented in clinical practice to limit patient exposure to COVID-19 while monitoring their treatment and follow-up. We sought to examine the satisfaction of patients with breast cancer (BC) who underwent teleconsultations during this period. | Alexandra Bizot;Maryam Karimi;Elie Rassy;Pierre Etienne Heudel;Christelle Levy;Laurence Vanlemmens;Catherine Uzan;Elise Deluche;Dominique Genet;Mahasti Saghatchian;Sylvie Giacchetti;Juline Grenier;Anne Patsouris;Véronique Dieras;Jean-Yves Pierga;Thierry Petit;Sylvain Ladoire;William Jacot;Marc-Antoine Benderra;Anne De Jesus;Suzette Delaloge;Matteo Lambertini;Barbara Pistilli | pubmed | |||||
66 | 34604490 | 10.1016/j.jemep.2021.100725 | Covid-19, museums, and art therapy. | 29 September 2021 00:00 | Editorial | FR | en | 2352-5525 | Laboratory Anthropology, Archaeology, Biology (LAAB), Paris-Saclay University, 2 avenue de la Source de la Bièvre, 78180 Montigny-Le-Bretonneux, France.;Department of Research and High Education, musée du quai Branly - Jacques Chirac, 222 rue de l'Université, 75007 Paris, France.;Fondation Anthropologie, Archéologie, Biologie - Institut de France, 23 quai de Conti, 75006 Paris, France. | Ethics, Medicine and Public Health | P Charlier | pubmed | ||||||
67 | 34585270 | 10.1007/s00134-021-06524-w | External validation of prognostic scores for COVID-19: a multicenter cohort study of patients hospitalized in Greater Paris University Hospitals. | 28 September 2021 00:00 | Journal Article | FR | en | 0342-4642,1432-1238 | Faculty of Medicine, AP-HP, Sorbonne Université, Paris, France.;Médecine Intensive-Réanimation, Centre Hospitalier Régional Universitaire de Tours, Tours, France.;Université de Tours, Tours, France.;WIND Department, TAL group, AP-HP, Paris, France.;Paris Saclay University, INRIA, CEA, Palaiseau, France.;Strategy and Transformation Department, AP-HP, Paris, France.;WIND Department, AP-HP, Paris, France.;Institut Pierre Louis d'Épidémiologie et de Santé Publique, UMR-S 1136 , Sorbonne Université, INSERM, Paris, France.;Clinical Research Platform, Saint Antoine Hospital, AP-HP, Paris, France.;Institut Pierre Louis d'Épidémiologie et de Santé Publique, UMR-S 1136 , Sorbonne Université, INSERM, Paris, France. olivier.steichen@aphp.fr.;Internal Medicine Department, Tenon Hospital, AP-HP, Sorbonne Université, Paris, France. olivier.steichen@aphp.fr.;Service de Médecine Interne, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France. olivier.steichen@aphp.fr. | Intensive Care Medicine | The Coronavirus disease 2019 (COVID-19) has led to an unparalleled influx of patients. Prognostic scores could help optimizing healthcare delivery, but most of them have not been comprehensively validated. We aim to externally validate existing prognostic scores for COVID-19. | Yannis Lombardi;Loris Azoyan;Piotr Szychowiak;Ali Bellamine;Guillaume Lemaitre;Mélodie Bernaux;Christel Daniel;Judith Leblanc;Quentin Riller;Olivier Steichen | COVID-19;Cohort studies;Intensive care units;Mortality;Prognosis;SARS-CoV-2 | pubmed | ||||
68 | 34597824 | 10.1016/j.otsr.2021.103088 | Descriptive analysis of pediatric orthopedic surgical emergencies during the COVID-19 lockdown: single-center observational study in a pandemic red-zone area in France. | 28 September 2021 00:00 | Journal Article | FR | en | 1877-0568 | Service de Chirurgie Infantile à Orientation Orthopédique, Hôpital Universitaire Robert Debré, Assistance Publique- Hôpitaux de Paris (AP-HP), Université de Paris, 48 Boulevard Sérurier, 75019 Paris, France. Electronic address: annelaure_simon@hotmail.com.;Service de Chirurgie Infantile à Orientation Orthopédique, Hôpital Universitaire Robert Debré, Assistance Publique- Hôpitaux de Paris (AP-HP), Université de Paris, 48 Boulevard Sérurier, 75019 Paris, France.;Service d'Anesthésie-Réanimation Pédiatrique, Hôpital Universitaire Robert Debré, Assistance Publique- Hôpitaux de Paris (AP-HP), Université de Paris, 48 Boulevard Sérurier, 75019 Paris, France. | Orthopaedics & Traumatology: Surgery & Research | Lockdown involved strict confinement of children at home, radically affecting their way of life, with increased risk of domestic accidents and the temptation to step outside of the legal framework. The aim of the present study was to analyze the impact of lockdown on pediatric emergency turnover in a university reference center situated in a high-risk "red zone" and to describe specific management measures. | Anne-Laure Simon;Sammy Kassab Hassan;Florence Julien-Marsollier;Adèle Happiette;Pascal Jehanno;Jean-Gabriel Delvaque;Brice Ilharreborde | COVID-19;SARS-CoV-2;lockdown;pediatric orthopedics;surgical emergencies | pubmed | ||||
69 | 34604719 | 10.1016/j.jobb.2021.08.005 | Team experience of nasopharyngeal samples reception, decontamination, and sorting during the covid-19 pandemic (2020) at institut pasteur côte d'ivoire. | 28 September 2021 00:00 | Journal Article;Review | CI;FR | en | 2588-9338 | Molecular Biology Platform/Institut Pasteur Côte d'Ivoire, Central Laboratory/University Hospital Center of Yopougon (Côte d'Ivoire).;Bacteriology and Virology Department, National Reference Center for Antibiotics/Institut Pasteur Côte d'Ivoire.;Molecular Biology Platform/Institut Pasteur Côte d'Ivoire.;Cell Biology Unit/Institut Pasteur Côte d'Ivoire.;Transport and packaging unit/Institut Pasteur Côte d'Ivoire.;Institut Pasteur Côte d'Ivoire. | Journal of Biosafety and Biosecurity | Molecular testing sensitivity, which allows for early diagnosis of the 2019 coronavirus disease (COVID-19), could be affected by sample quality, storage, and transportation timeframe to the laboratory, along with bias related to the pre-analytic phase. The present study reports the selection and decontamination of nasopharyngeal samples during COVID-19 management at the Institut Pasteur Côte d'Ivoire. The objective of this work was to organize sample reception management and report a complete picture of sample selection and decontamination in the context of diagnosis activity decentralization. An administrative note creating the selection and decontamination unit of nasopharyngeal samples initiated activities in May 2020. The required human resources and necessary materials were identified and put in place. Daily activity consisted of receiving, sorting, decontaminating, and sending nasopharyngeal samples to different diagnostic laboratories. Nonconformities were recorded monthly. Afte | Kolia Kouamé Innocent;Guédé Kipré Bertin;Kouassi Kan Stéphane;Obro Koby Albert;Odegue Kpadraux Danielle;Sina-Kouamé Sylvie Mireille;Yepri Banga Victor;Dosso Mireille | COVID-19;Côte d’Ivoire;Sorting and decontamination;nasopharyngeal sample | pubmed | ||||
70 | 34581528 | Early assessment of patients with COVID-19 and dyspnea using lung ultrasound scoring. | 28 September 2021 00:00 | Journal Article | FR | sp | Department of Emergency Medicine, Timone University Hospital, Marsella, Francia. UMR 1263 Center of Cardiovascular and Nutrition Research (C2VN), Aix-Marseille University, INSERM, INRAE, Marsella, Francia.;Department of Emergency Medicine, North University Hospital, Marsella, Francia. Aix-Marseille University, School of medicine - La Timone Medical Campus, EA 3279, CEReSS - Health Services Research and Quality of Life Center, Marsella, Francia.;Department of Emergency Medicine, Timone University Hospital, Marsella, Francia. Department of Emergency Medicine, North University Hospital, Marsella, Francia. Aix-Marseille University, School of medicine - La Timone Medical Campus, EA 3279, CEReSS - Health Services Research and Quality of Life Center, Marsella, Francia.;Department of Emergency Medicine, Timone University Hospital, Marsella, Francia.;Department of Emergency Medicine, North University Hospital, Marsella, Francia.;Aix-Marseille University, School of medicine - La Timone Medical C | The main objective was to evaluate the precision of the Modified Lung Ultrasound (MLUS score) for predicting the need for respiratory support in the first 48 hours in patients with dyspnea due to the coronavirus disease 2019 (COVID-19). The secondary objectives were 1) to compare the MLUS and National Early Warning Score 2 (NEWS2), as well as the combination of both scores, as predictors of severity according to the World Health Organization (WHO) Ordinal Scale for Clinical Improvement; and 2) to compare severity assessed by ultrasound scoring to severity assessed by lung computed tomography (CT). | Thibaut Markarian;Nicolas Persico;Antoine Roch;Dalia Ahriz;Chloe Taguet;Guillaume Birman;Adela Mahboubi;Justine Ducassou;Jeremy Bourenne;Laurent Zieleskiewicz;Xavier Bobbia;Pierre Michelet | COVID-19.;Emergency department.;Estado de Alarma Sanitaria.;State of emergency.;Urgencias. | pubmed | |||||||
71 | 34581763 | 10.1001/jamaneurol.2021.3619 | Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. | 28 September 2021 00:00 | Journal Article | MX;NO;IE;ES;IT;GR;DE;SE;BR;IL;PT;US;FI;IR;CR;SA;GB;CA;AT;CH;NL;FR;TR;AU | en | 2168-6149 | Department of Neurology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.;Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, University of Lisbon, Lisbon, Portugal.;Department of Neurology and Stroke, Eberhard-Karls University, Tuebingen, Germany.;Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tuebingen, Germany.;Department of Neurosciences and Cognition, Lille University Hospital, Lille, France.;Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.;Department of Internal Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.;Department of Neurology, Carlo Poma Hospital, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy.;Department of Internal Medicine, Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, the Netherland | JAMA Neurology | Thrombosis with thrombocytopenia syndrome (TTS) has been reported after vaccination with the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford-AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson). | Mayte Sánchez van Kammen;Diana Aguiar de Sousa;Sven Poli;Charlotte Cordonnier;Mirjam R Heldner;Anita van de Munckhof;Katarzyna Krzywicka;Thijs van Haaps;Alfonso Ciccone;Saskia Middeldorp;Marcel M Levi;Johanna A Kremer Hovinga;Suzanne Silvis;Sini Hiltunen;Maryam Mansour;Antonio Arauz;Miguel A Barboza;Thalia S Field;Georgios Tsivgoulis;Simon Nagel;Erik Lindgren;Turgut Tatlisumak;Katarina Jood;Jukka Putaala;Jose M Ferro;Marcel Arnold;Jonathan M Coutinho;Aarti R Sharma;Ahmed Elkady;Alberto Negro;Albrecht Günther;Alexander Gutschalk;Silvia Schönenberger;Alina Buture;Sean Murphy;Ana Paiva Nunes;Andreas Tiede;Anemon Puthuppallil Philip;Annerose Mengel;Antonio Medina;Åslög Hellström Vogel;Audrey Tawa;Avinash Aujayeb;Barbara Casolla;Brian Buck;Carla Zanferrari;Carlos Garcia-Esperon;Caroline Vayne;Catherine Legault;Christian Pfrepper;Clement Tracol;Cristina Soriano;Daniel Guisado-Alonso;David Bougon;Domenico S Zimatore;Dominik Michalski;Dylan Blacquiere;Elias Johansson;Elisa Cuadrado-Godia;Emman | pubmed | |||||
72 | 34598823 | 10.1016/j.vaccine.2021.09.033 | Research priorities to increase vaccination coverage in Europe (EU joint action on vaccination). | 28 September 2021 00:00 | Journal Article | FR;HU | en | 0264-410X | ISPED, Inserm Bordeaux Population Health, Univ Bordeaux, UMR 1219, Bordeaux, France, CHU Bordeaux, Pôle de Santé Publique, F-33000 Bordeaux, France. Electronic address: florence.francis@u-bordeaux.fr.;Laboratory on Engineering & Management Intelligence, Research Group of Operations Research & Decision Systems, Institute for Computer Science & Control, Eötvös Loránd Research Network (ELKH SZTAKI), Budapest, Hungary, Department of Operations Research & Actuarial Sciences, Corvinus University of Budapest, Hungary.;Department of Distributed Systems, Institute for Computer Science & Control, Eötvös Loránd Research Network (ELKH SZTAKI), Budapest, Hungary.;Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.;Department of Clinical Immunology and Infectious Diseases - Henri Mondor Hospital, France, Vaccine Research Institute, Université Paris Est Créteil, Paris, France. | Vaccine | Deciding how best to invest in healthcare is never an easy task and prioritization is therefore an area of great interest for policymakers. Too low public vaccine confidence, which results in insufficient vaccine uptake, remains an area of concern for EU policy-makers. Within the European Joint action on vaccination, a work-package dedicated to research aims to define tools and methods for priority-setting in the field of vaccination research. We therefore propose a prioritization framework to identify research priorities towards generating and synthesizing evidence to support policies and strategies aiming at increasing vaccine coverage. | Florence Francis-Oliviero;Sandor Bozoki;András Micsik;Marie Paule Kieny;Jean-Daniel Lelièvre | Multi-criteria decision analysis;Research priorities;Vaccination | pubmed | ||||
73 | 34580225 | 10.1073/pnas.2108576118 | Trust in scientists in times of pandemic: Panel evidence from 12 countries. | 28 September 2021 00:00 | Journal Article;Research Support, Non-U.S. Gov't | FR;US;GB | en | 0027-8424,1091-6490 | Economics Department, Ecole des Hautes Etudes Commerciales (HEC) Paris, 78350 Jouy-en-Josas, France, algan@hec.fr.;Economics Department, Ecole Normale Supérieure, 75005 Paris, France.;Economics Department, Sciences Po, 75007 Paris, France.;Political Science Department, Sciences Po, 75007 Paris, France.;Economics Department, Harvard University, Cambridge, MA 02138. | Proceedings of the National Academy of Sciences | This article analyzes the specific and critical role of trust in scientists on both the support for and compliance with nonpharmaceutical interventions (NPIs) during the COVID-19 pandemic. We exploit large-scale, longitudinal, and representative surveys for 12 countries over the period from March to December 2020, and we complement the analysis with experimental data. We find that trust in scientists is the key driving force behind individual support for and compliance with NPIs and for favorable attitudes toward vaccination. The effect of trust in government is more ambiguous and tends to diminish support for and compliance with NPIs in countries where the recommendations from scientists and the government were not aligned. Trust in others also has seemingly paradoxical effects: in countries where social trust is high, the support for NPIs is low due to higher expectations that others will voluntary social distance. Our individual-level longitudinal data also allows us to evaluate the | Yann Algan;Daniel Cohen;Eva Davoine;Martial Foucault;Stefanie Stantcheva | COVID-19;trust in governments;trust in others;trust in scientists | [{"agency": "European Research Council", "country": "International"}] | European Research Council | pubmed | ||
74 | 34581431 | 10.5603/cj.a2021.0104 | Troponin T in COVID-19 hospitalized patients: Kinetics matter. | 28 September 2021 00:00 | Journal Article | FR;BE | en | 1898-018X,1897-5593 | Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel, Belgium. marialuiza.luchian@yahoo.com.;Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel, Belgium.;b. CHU Limoges, Hôpital Dupuytren, Service Cardiologie, Limoges, France.;Vrije Universiteit Brussel (VUB), Faculty of Medicine and Pharmacy, 1090 Brussel, Belgium.;. University Hospital of Ambroise Pare, Mons, Belgium. | Cardiology Journal | Coronavirus disease 2019 (COVID-19) emerged as a worldwide health crisis, overwhelming healthcare systems. Elevated cardiac troponin T (cTn T) at admission was associated with increased in-hospital mortality. However, data addressing the role of cTn T in major adverse cardiovascular events (MACE) in COVID-19 are scarce. Therefore, we assessed the role of baseline cTn T and cTn T kinetics for MACE and in-hospital mortality prediction in COVID-19. | Maria-Luiza Luchian;Andreea Iulia Motoc;Stijn Lochy;Julien Magne;Bram Roosens;Dries Belsack;Karen Van den Bussche;Berlinde von Kemp;Xavier Galloo;Clara François;Esther Scheirlynck;Sven Boeckstaens;Tom De Potter;Lucie Seyler;Johan van Laethem;Sophie Hennebicq;Caroline Weytjens;Steven Droogmans;Bernard Cosyns | COVID-19;cardiac troponin;kinetics;major cardiovascular adverse events;mortality;myocardial injury | pubmed | ||||
75 | 34581611 | The critical role of microvesicles in the modulation of renin-angiotensin-aldosterone system in endothelial homeostasis. | 28 September 2021 00:00 | Letter;Comment | FR;US | en | Department of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.;INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle, University of Strasbourg, Strasbourg, France. | Aldosterone;Homeostasis;Renin;Renin-Angiotensin System | Antonin Trimaille;Benjamin Marchandot;Kensuke Matsushita;Olivier Morel | COVID-19;angiotensin;coronary artery disease;endothelium;microvesicles | pubmed | |||||||
76 | 34597664 | 10.1016/j.envres.2021.112141 | Origin of COVID-19: Dismissing the Mojiang mine theory and the laboratory accident narrative. | 28 September 2021 00:00 | Journal Article | FR | en | 0013-9351 | Cirad, UMR 17, Intertryp, Montpellier, France. Electronic address: roger.frutos@cirad.fr.;Laveran Military Teaching Hospital, Marseille, France, IHU-Méditerranée Infection, Marseille, France, Aix Marseille Univ, IRD, AP-HM, SSA, Vitrome, Marseille, France.;Laveran Military Teaching Hospital, Marseille, France.;Espace-Dev, Université de Montpellier, Montpellier, France.;IHU-Méditerranée Infection, Marseille, France.;IHU-Méditerranée Infection, Marseille, France, CNRS, Marseille, France. | Environmental Research | The origin of SARS-CoV-2 is still the subject of a controversial debate. The natural origin theory is confronted to the laboratory leak theory. The latter is composite and comprises contradictory theories, one being the leak of a naturally occurring virus and the other the leak of a genetically engineered virus. The laboratory leak theory is essentially based on a publication by Rahalkar and Bahulikar in 2020 linking SARS-CoV-2 to the Mojiang mine incident in 2012 during which six miners fell sick and three died. We analyzed the clinical reports. The diagnosis is not that of COVID-19 or SARS. SARS-CoV-2 was not present in the Mojiang mine. We also bring arguments against the laboratory leak narrative. | Roger Frutos;Emilie Javelle;Celine Barberot;Laurent Gavotte;Herve Tissot-Dupont;Christian A Devaux | COVID-19;Clinical diagnosis;Mojiang mine;Origin of SARS-CoV-2 | pubmed | ||||
77 | 34584248 | A public-private partnership model for COVID-19 diagnostics. | 28 September 2021 00:00 | Letter | NL;CH;BE;FR | en | Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.;Laboratory of Medical Microbiology, Stichting PAMM, Veldhoven, the Netherlands.;InActiv Blue, Beernem, Belgium.;Biogazelle, Zwijnaarde, Belgium.;Department of Medical Microbiology, University Medical Center, Utrecht, the Netherlands.;Tecan labwerx, Tecan Trading AG, Männedorf, Switzerland.;National Screening Laboratory Sanquin, Sanquin Diagnostics, Amsterdam, the Netherlands.;Bodegro B.V, Breda, the Netherlands.;HiFiBio Therapeutics, Saint-Jacques, France.;Department of Laboratory Automation, Genmab B.V., Utrecht, the Netherlands.;Laboratory of Medical Microbiology, Stichting PAMM, Veldhoven, the Netherlands. l.van.der.velden@pamm.nl.;Department of Laboratory Automation, Genmab B.V., Utrecht, the Netherlands. mbh@genmab.com.;Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. w.laat@hubrecht.eu.;Oncode Institute, Hubrecht Inst | Peter H L Krijger;Tim A Hoek;Sanne Boersma;Lieke I P M Donders;Maaike M C Broeders;Mark Pieterse;Pim W Toonen;Ive Logister;Bram M P Verhagen;Marjon J A M Verstegen;Thomas W van Ravesteyn;Rene J T M Roymans;Francesca Mattiroli;Jo Vandesompele;Monique Nijhuis;Stefan Meijer;Anton van Weert;Edwin Dekker;Fred J Dom;Rob Ruijtenbeek;Lieven B J van der Velden;Jeroen H B van de Bovenkamp;Martijn Bosch;Wouter de Laat;Marvin E Tanenbaum | pubmed | |||||||||
78 | 34579570 | 10.1128/mbio.02371-21 | Betacoronavirus Assembly: Clues and Perspectives for Elucidating SARS-CoV-2 Particle Formation and Egress. | 28 September 2021 00:00 | Journal Article | FR | en | 2150-7511 | Institut de Recherche en Infectiologie de Montpellier, Université de Montpellier, CNRS UMR9004, Montpellier, France. | mBio | In 2019, a new pandemic virus belonging to the betacoronavirus family emerged, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This new coronavirus appeared in Wuhan, China, and is responsible for severe respiratory pneumonia in humans, namely, coronavirus disease 2019 (COVID-19). Having infected almost 200 million people worldwide and caused more than 4.1 million deaths as of today, this new disease has raised a significant number of questions about its molecular mechanism of replication and, in particular, how infectious viral particles are produced. Although viral entry is well characterized, the full assembly steps of SARS-CoV-2 have still not been fully described. Coronaviruses, including SARS-CoV-2, have four main structural proteins, namely, the spike glycoprotein (S), the membrane glycoprotein (M), the envelope protein (E), and the nucleocapsid protein (N). All these proteins have key roles in the process of coronavirus assembly and budding. In this review, we gat | David Bracquemond;Delphine Muriaux | SARS-CoV-2;egress;viral assembly | pubmed | ||||
79 | 34582692 | 10.22605/rrh6366 | Distance learning in the COVID-19 pandemic: acceptance and attitudes of physical therapy and rehabilitation students in Turkey. | 28 September 2021 00:00 | Journal Article | FR;TR | en | 1445-6354 | School of Physical Therapy and Rehabilitation, Pamukkale University, Denizli, Turkey raziyesavkin@hotmail.com.;Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Muş Alparslan University, Muş, Turkey gokhan2803@gmail.com.;School of Physical Therapy and Rehabilitation, Pamukkale University, Denizli, Turkey nasuk@pau.edu.tr. | Rural and Remote Health | Attitude;COVID-19__epidemiology;Education, Distance__methods;Female;Humans;Male;Pandemics;Physical Therapy Modalities;Physical Therapy Specialty__education;SARS-CoV-2;Students, Health Occupations__psychology;Turkey | To reduce the rate of spread of the COVID-19 pandemic in Turkey, distance education was initiated in all universities on 23 March 2020. Distance learning had not been experienced in physical therapy and rehabilitation education before the COVID-19 outbreak. This study aimed to (a) determine the acceptance and attitudes of Pamukkale University Physical Therapy and Rehabilitation undergraduate students towards distance learning during the COVID-19 outbreak and (b) compare the results among years. | Raziye Şavkın;Gökhan Bayrak;Nihal Büker | COVID-19;Turkey;distance learning;health student;sense of community;acceptance and attitudes | pubmed | |||
80 | 34569939 | 10.7554/elife.69302 | Quantifying the relationship between SARS-CoV-2 viral load and infectiousness. | 27 September 2021 00:00 | Journal Article;Research Support, Non-U.S. Gov't | ES;GN;PG;FR;GB | en | 2050-084X | Université de Paris, IAME, INSERM, Paris, France.;Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, France.;Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.;Lihir Medical Centre, International SOS, Londolovit, Papua New Guinea.;Hospital Universitari Parc Taulí, Sabadell, Spain.;Facultat de Medicina-Universitat de Barcelona, Barcelona, Spain.;London School of Hygiene and Tropical Medicine, London, United Kingdom.;Hospital for Tropical Diseases, London, United Kingdom.;Division of infection and Immunity, University College London, London, United Kingdom. | eLife | Adult;COVID-19__immunology;COVID-19 Vaccines__administration & dosage;Cohort Studies;Contact Tracing__statistics & numerical data;Female;Humans;Logistic Models;Male;Middle Aged;Risk Factors;SARS-CoV-2__immunology;Viral Load;Virus Replication__immunology;Young Adult | The relationship between SARS-CoV-2 viral load and infectiousness is poorly known. Using data from a cohort of cases and high-risk contacts, we reconstructed viral load at the time of contact and inferred the probability of infection. The effect of viral load was larger in household contacts than in non-household contacts, with a transmission probability as large as 48% when the viral load was greater than 1010 copies per mL. The transmission probability peaked at symptom onset, with a mean probability of transmission of 29%, with large individual variations. The model also projects the effects of variants on disease transmission. Based on the current knowledge that viral load is increased by two- to eightfold with variants of concern and assuming no changes in the pattern of contacts across variants, the model predicts that larger viral load levels could lead to a relative increase in the probability of transmission of 24% to 58% in household contacts, and of 15% to 39% in non-househo | Aurélien Marc;Marion Kerioui;François Blanquart;Julie Bertrand;Oriol Mitjà;Marc Corbacho-Monné;Michael Marks;Jeremie Guedj | SARS-CoV-2;computational biology;epidemiology;human;infectious disease;infectious diseases;microbiology | [{"grantid": "INV-017335", "agency": "Bill and Melinda Gates Foundation", "country": ""}, {"grantid": "ANR-20-COVI-0018", "agency": "French National Research Agency", "country": ""}, {"grantid": "ERC Starting Grant under the European Union's Horizon 2020 research and innovation programme", "agency": "European Research Council", "country": "International"}, {"grantid": "Crowdfunding campaign", "agency": "YoMeCorono", "country": ""}] | Bill and Melinda Gates Foundation;French National Research Agency;European Research Council;YoMeCorono | pubmed | |
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